论文部分内容阅读
目的探讨亚急性1,2-二氯乙烷(1,2-Dichloroethane,1,2-DCE)中毒性脑病的影像学表现,提高对本病的认识。方法对2014年2月—2016年4月在温州医科大学附属第二医院和温州医科大学附属苍南医院12例1,2-DCE中毒性脑病患者的CT、MR影像学表现及特征作回顾性分析。结果 CT表现:两侧大脑半球白质区广泛性对称性密度减低,边缘模糊,皮髓质分界不清,脑回肿胀,脑沟变浅;两侧苍白球、内囊后肢、外囊及丘脑密度减低,脑干肿胀,密度减低,周围脑池受压变窄;两侧小脑齿状核斑片状密度减低。MR表现:两侧大脑皮层下弓形白质纤维区广泛性对称性“U”形T_1WI低信号、T_2WI、T_2-FLAIR高信号,伴脑回变窄、脑沟变浅或消失,未见累及半卵圆中心区;两侧豆状核、外囊、小脑齿状核也呈条片状、小片状T_1WI低信号、T_2WI、T_2-FLAIR高信号影。DWI序列上述病变区呈明显高信号,边界较清,ADC呈低信号。结论亚急性1,2-DCE中毒性脑病具有特定的发病环境和突发性头痛、意识障碍为主的临床症状,MR检查比CT能更敏感地反映病变累及的部位、范围、水肿类型及严重程度,并具有一定的特征性,为临床及时、准确诊断中毒性脑病提供重要依据。
Objective To investigate the imaging findings of 1,2-Dichloroethane (1,2-DCE) toxic encephalopathy and to improve its understanding of the disease. Methods The CT and MR imaging findings and features of 12 patients with 1,2-DCE toxic encephalopathy in the Second Affiliated Hospital of Wenzhou Medical University and Cangnan Hospital Affiliated to Wenzhou Medical University from February 2014 to April 2016 were retrospectively analyzed . Results The CT findings showed that the symmetry of the white matter in the bilateral hemispheres was diminished on both sides of the hemisphere, the edges were blurred, the boundaries of the cortex and medulla were not clear, the brain was swollen, and the sulci became shallow. The globus pallidus, Reduce the swelling of the brain stem, reduce the density, narrowing of the pressure around the cerebral cistern; bilateral cerebellar dentatus patch density reduction. MR showed extensive symmetry of bilateral arcuate white matter fibers on both sides of the cerebral cortex, “U” shaped T_1WI low signal, T_2WI, T_2-FLAIR high signal, with narrowing of the brain back, sulci shallow or disappeared, no involvement Semi-oval center; both sides of lentiform nucleus, outer capsule, cerebellar dentate core also strip-like, small piece of T_1WI low signal, T_2WI, T_2-FLAIR high signal. DWI sequence was significantly higher in the above lesions, border clear, ADC was low signal. Conclusions Subacute 1,2-DCE toxic encephalopathy has specific clinical conditions, such as sudden onset of headache and disturbance of consciousness. MR examination can reflect more sensitively the location, extent, edema type and severity of lesions than CT Degree, and has a certain characteristic, for clinical timely and accurate diagnosis of toxic encephalopathy provide an important basis.