Heteroclinic bifurcations in four dimensional vector fields are investigated by setting up a local coordinates near a rough heteroclinic loop. This heteroclinic loop has a principal heteroclinic orbit and a non-principal heteroclinic orbit that takes orbit flip. The existence, nonexistence, coexistence and uniqueness of the 1-heteroclinic loop, 1-homoclinic orbit and 1-periodic orbit are studied. The existence of the two-fold or three-fold 1-periodic orbit is also obtained.