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目的:探讨消疲怡神口服液抗应激的作用机理。方法:观察了消疲怡神口服液对强制冷水游泳大鼠模型血清单胺类物质、肾上腺抗坏血酸和下丘脑垂体单胺类递质含量及胸腺指数的影响。结果:消疲怡神口服液可以拮抗应激所致血清多巴胺、5羟色胺含量升高和肾上腺抗坏血酸含量降低,使降低的下丘脑垂体去甲肾上腺素、5羟色胺含量回升,但对胸腺指数无明显影响。结论:消疲怡神口服液的作用机制与其对机体下丘脑—垂体—肾上腺—胸腺轴的调节有关。
Objective: To investigate the anti-stress mechanism of Xiaoyi Yishen oral liquid. Methods: The effects of Xiaoshao Yishen oral liquid on serum monoamines, adrenal ascorbic acid, hypothalamic pituitary monoamine transmitters and thymus index in rats with strong cooling water swimming were observed. Results: Xiaomai Yishen Oral Liquid could antagonize the stress caused by the increase of serum dopamine, serotonin and adrenal ascorbate, and decreased the hypothalamic norepinephrine norepinephrine and serotonin content, but no obvious thymus index. influences. Conclusion: The mechanism of Xiaomai Yishen oral solution is related to its regulation of the hypothalamus-pituitary-adrenal-thymus axis.