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中药川芎系活血化淤、行气定痛的药物,对急慢性缺血性血管疾病有肯定的疗效。鉴于川芎总生物碱具有生物活性,对其中Ⅰ号碱(TMP)的药理作用进行了研究;我们对其中Ⅲ号碱(Perlolyrine)在化学合成及同位素标记合成的基础上,进行了有关冠心病药理作用的实验研究。实验方法和结果 (一)Perlolyrine对小鼠低压缺氧耐力的影响取小鼠(18—22g)30只,雄雌各半,随机均分两组,实验组小鼠用300mg/kg的Pe-rlolyrine灌胃,对照组小鼠用同体积的0.2％
Traditional Chinese medicine Chuanxiong is a drug that promotes blood stasis and relieves pain, and it has a positive effect on acute and chronic ischemic vascular diseases. In view of the biological activity of total alkaloids from Rhizome of Ligusticum chuanxiong, the pharmacological action of the base I (TMP) was studied; we conducted the relevant pharmacology of coronary heart disease on the basis of chemical synthesis and isotopic labeling of the base of Perlolyrine III. Experimental study of the role. Experimental methods and results (1) Effect of Perlolyrine on hypoxia tolerance in mice 30 (18-22g) mice (male and female, half male and half female) were randomly divided into two groups. The mice in the experimental group were treated with 300 mg/kg of Pe- Rlolyrine gavage, 0.2% of the same volume of mice in the control group