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生物利用度的测定可用血、尿作为样本,也可以用唾液来进行。唾液的收集和处理都比较容易,因此本文选用唾液作为生物利用度测定样品。为了确定用唾液测定的可靠性,对测定方法作了回收实验和唾液与血清的对比实验,结果回收率为101.7%,与血清的比率为1.018,与文献值1.02相近。并选取了3个样品进行了生物利用度测定,将结果与体外溶出速率相对照,吸收速率与溶出速率有相关性。认为可以反映生物利用度的情况。
Bioavailability can be measured using blood, urine as a sample, you can also use saliva to carry out. Saliva collection and treatment are relatively easy, so this article selected saliva as a bioassay sample. In order to determine the reliability of saliva determination, the recovery test and the saliva-serum test were performed. The recovery was 101.7% and the ratio to serum was 1.018, which was similar to the literature value of 1.02. Three samples were selected for bioavailability determination. The results were compared with the dissolution rate in vitro, and the correlation between absorption rate and dissolution rate. Think it can reflect the bioavailability of the situation.