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药源性高血压为常见药物不良反应之一,其发病机制包括交感神经活动亢进,肾性水钠潴留,肾素-血管紧张素-醛固酮系统激活,以及动脉弹性功能和结构改变。临床表现为血压升高、反跳现象,甚至出现高血压危象。高危因素包括高龄、性别、遗传原因、既往高血压病史、超重、钠敏感、基础疾病。高危人群应避免使用可致血压升高的药物;必须使用时,应从最小剂量开始并应监测血压水平。一旦出现高血压应立即停药或减少剂量,并予对症治疗。
Drug-induced hypertension is one of the common adverse drug reactions. Its pathogenesis includes hyperactivity of sympathetic activity, renal sodium and water retention, activation of renin-angiotensin-aldosterone system, and changes of arterial elasticity and structure. Clinical manifestations of hypertension, rebound phenomenon, and even hypertensive crisis. High risk factors include age, gender, genetic causes, previous history of hypertension, overweight, sodium sensitivity, underlying disease. High-risk groups should avoid the use of drugs that can cause blood pressure; must be used, should start with the minimum dose and blood pressure levels should be monitored. In the event of hypertension should immediately stop or reduce the dose, and symptomatic treatment.