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1、“B”。药物半衰期可分血浆半衰期和生物半衰期,除标明生物半衰期外,一般所说的半衰期是指血浆半衰期,即血中药物浓度降低一半所需的时间。 2、“E”。药物的治疗指数是指药物的致死量或中毒量与有效量(治疗量)的比值。从指数大小可以估计一个药物的安全程度,比例越大,安全程度也越大。在实验研究中,往往以半数致死量(LD_(50))和半数有效量(ED_(50))之比作为测定指标。“A”项叙述称为安全范围,而非治疗指数。其余答案无意义。 3、“C”。口服保泰松后,大部经肝微粒体中药酶代谢,其代谢产物为羟基保泰松和γ—羟基保泰松。羟基保泰松仍具有显著的抗风湿和潴钠作用。扑热息痛经肝代谢后排出体外。苯巴比妥约
1, “B”. Half-life of the drug can be divided into plasma half-life and biological half-life, in addition to indicating biological half-life, the so-called half-life refers to the plasma half-life, that is, the blood concentration of drugs half the time required. 2, “E”. The therapeutic index of a drug refers to the ratio of the lethal or toxic dose of the drug to the effective amount (therapeutic amount). From the index size can estimate the safety of a drug, the greater the proportion, the greater the degree of safety. In the experimental study, the ratio of LD50 (50) to the median effective dose (ED50) was often used as the measurement index. The “A” narrative is called the safety margin, not the treatment index. The rest of the answers are meaningless. 3, “C”. Phenylbutazone after oral administration, most of the liver microsomal enzyme metabolism, the metabolites of hydroxy phenylbutazone and γ-hydroxy phenylbutazone. Phenylbutazone still has significant anti-rheumatoid and retention of sodium role. Paracetamol excreted by the liver after metabolism. Phenobarbital about