狒狒免疫系统的基因序列与人类高度同源,因此,狒狒可能是评价人用疫苗的有价值动物模型。有报道显示,南非大型狒狒在野生及笼养环境下均可感染结核杆菌和牛分枝杆菌。但尚不了解狒狒对卡介苗(BCG)的免疫应答情况。为此,南非开普敦大学的Chege等用BCG接种大型狒狒,观察其对BCG的 The baboon’s immune system has a gene sequence that is highly homologous to humans, so baboons may be valuable animal models for evaluating human vaccines. It has been reported that large-scale baboons in South Africa can infect Mycobacterium tuberculosis and Mycobacterium bovis in both wild and caged environments. However, the baboon’s immune response to BCG is unknown. To this end, Chege and other South Africa University of Cape Town BCG vaccinated large baboons to observe its BCG