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目的研究南京市主要细菌性病原体致食源性疾病负担,提出食源性疾病监测策略。方法根据南京市11个区17家食源性疾病哨点医院主动监测和食源性疾病负担调查结果,结合各主要细菌性病原体的食源性比例等各项乘数,获得人群中各主要细菌性病原体的发病率及疾病负担。结果 2015年全市共采集1 208份食源性疑似病例生物标本,检出非伤寒沙门氏菌31株、副溶血性弧菌20株、致泻大肠埃希氏菌15株,检出率分别为2.57%、1.66%、2.56%;全市疾病负担调查3 600人,急性胃肠炎的月患病率为3.9%,年发病率为0.55次/人年;推算出南京市非伤寒沙门氏菌食源性感染发病率为1 292/10万,0~4岁年龄组发病率最高(3 481/10万);副溶血性弧菌食源性感染发病率为619/10万,15~24岁年龄组发病率最高(2 076/10万),致泻性大肠埃希氏菌的食源性感染发病率为1 653/10万,5~14岁年龄组发病率最高(5 263/10万)。结论南京市非伤寒沙门氏菌、副溶血性弧菌、致泻性大肠埃希氏菌感染负担较重,儿童非伤寒沙门氏菌和致泻性大肠埃希氏菌、青壮年副溶血性弧菌的感染负担尤为突出,针对不同人群加强相应病原体的监测,同时应进一步完善相关监测及研究,为制定相应的风险控制措施提供科学依据。
Objective To study the burden of food borne diseases caused by the main bacterial pathogens in Nanjing and to propose a foodborne disease surveillance strategy. Methods According to the results of surveys on active surveillance and food borne diseases in 17 sentinelly sentinel hospitals in 11 districts in Nanjing and the multiplication factors such as foodborne proportions of major bacterial pathogens, The incidence of pathogens and disease burden. Results In 2015, a total of 1 208 food-borne suspected cases were collected and 31 non-typhoid Salmonella, 20 strains of Vibrio parahaemolyticus and 15 strains of diarrhea-causing Escherichia coli were detected, the detection rates were 2.57% , 1.66%, 2.56%. The city’s disease burden survey of 3 600 people, the monthly prevalence of acute gastroenteritis was 3.9%, the annual incidence rate was 0.55 times / person-year; Nanjing non-destructive enteric-based foodborne infections were calculated The prevalence was 1 292/10 million, with the highest incidence in the 0-4 age group (3 481/10 000). The incidence of Vibrio parahaemolyticus foodborne infection was 619/10 million and the incidence in the 15-24 age group The highest incidence was 2076/10 million. The incidence of food-borne infections caused by diarrheal Escherichia coli was 16.53 / 10,000. The highest incidence was found in the age group of 5-14 years (5263/10000). Conclusions The non-typhoid Salmonella, Vibrio parahaemolyticus and diarrheal Escherichia coli in Nanjing have a heavy burden of infection. The infection burden of non-typhoid Salmonella and diarrheal Escherichia coli and Vibrio parahaemolyticus in children Especially for different populations to strengthen the monitoring of the corresponding pathogens, should also further improve the relevant monitoring and research, to provide the scientific basis for the development of appropriate risk control measures.