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目的研究甘草对阿普唑仑在大鼠体内药动学特征的影响。方法将14只SD大鼠随机分为对照组与实验组,分别予生理盐水和甘草提取物(0.5 g·kg~(-1),qd×7d),灌胃给予阿普唑仑20 mg·kg~(-1)后按时间点连续采样,采用HPLC法测定血药浓度。采用DAS 2.0软件计算并比较主要药动学参数。结果对照组和实验组中阿普唑仑的主要药动学参数:ρ_(max)分别为(1 015.24±706.67)、(1170.81±682.69)μg·L(~1),t_(max)分别为(0.52±0.18)、(0.52±0.18)h,t_(1/2)分别为(3.57±0.91)、(3.21±0.61)h,AUC_(0→12h)分别为(1 067.03±482.19)、(1 283.76±504.07)μg.h·L~(-1),AUC_(0→∞)分别为(1 081.17±478.07)、(1 299.04±501.17)μg·h·L~(-1)MRT分别为(1.77±0.75)、(1.78±0.64)h。各参数在两组间比较,差异均无统计学意义(P>0.05)。结论甘草连续给药7 d后不影响阿普唑仑在大鼠体内的药动学特征。
Objective To study the effect of licorice on the pharmacokinetics of alprazolam in rats. Methods Fourteen Sprague-Dawley rats were randomly divided into control group and experimental group, which were treated with saline and licorice extract (0.5 g · kg -1, qd × 7 d) kg ~ (-1) after continuous sampling at the time point, using HPLC determination of plasma concentration. DAS 2.0 software was used to calculate and compare the main pharmacokinetic parameters. Results The main pharmacokinetic parameters of alprazolam in control group and experimental group were ρ max (1 015.24 ± 706.67) and (1170.81 ± 682.69) μg · L -1, respectively, and t max were (0.52 ± 0.18), (0.52 ± 0.18) h and t 1/2 were (3.57 ± 0.91) and (3.21 ± 0.61) h, respectively. The AUC_ (0 → 12h) were (1 067.03 ± 482.19) 1 283.76 ± 504.07) μg.h · L -1, AUC_ (0 → ∞) were (1 081.17 ± 478.07) and (1 299.04 ± 501.17) μg · h · L -1 MRT were (1.77 ± 0.75), (1.78 ± 0.64) h. The parameters between the two groups, the difference was not statistically significant (P> 0.05). Conclusion Licorice after continuous administration of 7 d does not affect the pharmacokinetics of alprazolam in rats.