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一、盐酸小蘖鹼的提制根据西南中药研究所从黄柏提制盐酸小蘖鹼敏的报告有四种方法:(1)盐酸沉淀法(2)酒精盐酸法,(3)通盐酸气体沉淀法,(4)饱和食盐水沉析法。这几种方法大体上相似,我们会仿用过盐析法为便于参考兹将前后两种方法摘录如下:(1)盐酸沉淀法:将黄柏用碎粉机或石磨碎成粗粉(10目篩),用70%酒精浸渍4次,每次6小时(生药与醇的比例为1:3-3.5),至浸出液对碘化钾试剂呈极微混浊为止,浸液减压浓缩至几乎不含酒精,放置过夜,滤去树脂状物质,滤液加过量浓盐酸(生药100公斤加比重1.18盐酸约1.4公斤)静置,沉淀在离心机中分离,用95%酒精洗
First, the preparation of berberine hydrochloride According to the report of the Southwest Institute of Traditional Chinese Medicine from Berberine berberine hydrochloride, there are four methods: (1) hydrochloric acid precipitation method (2) alcohol hydrochloric acid method, (3) hydrochloric acid gas precipitation Method, (4) saturated salt solution precipitation method. These methods are similar in principle. We will use the salting out method for reference. The following two methods are excerpted as follows: (1) Hydrochloric acid precipitation method: The cork is grinded into coarse powder with a flour mill or stone (10 Mesh sieve), dip 4 times with 70% alcohol for 6 hours (1:3-3.5 ratio of crude drug and alcohol) until the leachate is extremely cloudy with potassium iodide reagent. The alcohol was left standing overnight and the resinous substance was filtered off. The filtrate was added with concentrated hydrochloric acid in excess (100 kg of crude drug and 1.4 kg of specific gravity 1.18 hydrochloric acid). The precipitate was separated in a centrifuge and washed with 95% alcohol.