患女,12岁,因两下肢无力,步态异常,双眼球固定,视力障碍7天入院。无发热、头痛及语音减低,1月前曾有上感史。系G_1P_1,生长发育与正常同龄儿无异,家族无遗传性病史。体检:神清,营养发育中等,被动体位,步态不稳,双睑能闭合,眼球固定,对光反应迟钝,复机,面纹对称,伸舌居中。颈软,心肺、腹部未见异常。两上肢桡骨膜反应存在,肱二、三头肌腱反射减弱,四肢肌力为Ⅳ级,两下肢痛觉存在,腹壁反射、Romberg氏征、指鼻试验、跟腱反射均(+),其它病理反射(-)。检查:EEG、MRI、CSF、肌电图、血生化均正常,2周 Affected woman, 12 years old, due to weakness of both lower extremities, abnormal gait, fixation of both eyes, visual impairment 7 days admission. No fever, headache and speech reduction, there was a sense of history before January. Department of G_1P_1, growth and development with the same age as normal children, family history of no genetic disease. Physical examination: God clear, medium nutritional development, passive posture, gait instability, double eyelid can be closed, the eye fixed, unresponsive to light, complex machine, facial symmetry, middle tongue. Neck soft, heart and lungs, abdomen no exception. Radial periosteal reaction of both upper extremities existed. The brachial and triceps tendon reflexes were weakened, the muscle strength of the four limbs was grade IV, the presence of pain in both lower extremity, abdominal wall reflex, Romberg’s sign, nasolabial test, Achilles tendon reflex (+) and other pathological reflex (-). Check: EEG, MRI, CSF, EMG, blood biochemistry are normal, 2 weeks