用肾包膜下移植法将经裸鼠传代的人卵巢癌细胞系ＳＫＯＶ３，移植于纯系小鼠Ｃ５７ＢＬ／６和杂交一代小鼠ＢＣＦ１和ＢＤＦ１的肾包膜下，观察移植后不同时间移植瘤的体积和病理组织学变化。结果表明，移植瘤体积在术后第６～８天最大，淋巴细胞浸润在８～１２天最严重，瘤细胞在移植后１０天内形态仍完整。同时比较了３种品系小鼠的差异，为肿瘤免疫学研究提供了短期实验的人卵巢癌免疫功能动物模型。 Human ovarian cancer cell line SKOV3, which was passaged by nude mice, was transplanted into the renal capsule of both C57BL / 6 and BCF1 and BDF1 mice of purebred mice, and the transplanted tumor at different times after transplantation The volume and histopathological changes. The results showed that the volume of xenograft tumor was the largest at 6 to 8 days after operation, and the lymphocyte infiltration was most serious in 8 to 12 days. The tumor cells remained intact within 10 days after transplantation. At the same time, the differences between the three strains of mice were compared, and a short-term experimental animal model of immune function of human ovarian cancer was provided for tumor immunology research.