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目的探讨表皮生长因子受体和血管内皮生长因子在乳腺癌中的表达及其意义。方法收集乳腺癌标本74例,乳腺纤维腺瘤标本30份,应用免疫组织化学S-P法检测表皮生长因子(EGFR)和血管内皮生长因子(VEGF)的表达,并分析它们的相关性。结果 EGFR和VEGF在乳腺纤维腺瘤中阳性率分别为10%(3/30)和13.3%(4/30);在乳腺癌中阳性率分别为65%(48/74)和68%(50/74)。它们在乳腺癌中的阳性率明显高于腺瘤中的阳性率(P<0.05),在浸润性乳腺癌中的阳性率明显高于非浸润性乳腺癌的阳性率(P<0.05),淋巴结阳性的乳腺癌其阳性率明显高于淋巴结阴性者(P<0.05)。结论 EGFR和VEGF的高表达可能与乳腺癌的发生、发展和转移相关,对指导化疗、靶向治疗以及预后的判断可能具有一定的临床意义。
Objective To investigate the expression and significance of epidermal growth factor receptor and vascular endothelial growth factor in breast cancer. Methods 74 cases of breast cancer and 30 cases of breast fibroadenoma were collected. The expressions of epidermal growth factor (EGFR) and vascular endothelial growth factor (VEGF) were detected by immunohistochemical S-P method and their correlation was analyzed. Results The positive rates of EGFR and VEGF in breast fibroadenoma were 10% (3/30) and 13.3% (4/30), respectively. The positive rates of EGFR and VEGF in breast cancer were 65% (48/74) and 68% (50% / 74). Their positive rates in breast cancer were significantly higher than those in adenomas (P <0.05), and their positive rates in invasive breast cancer were significantly higher than those in non-invasive breast cancer (P <0.05) The positive rate of positive breast cancer was significantly higher than that of lymph node negative (P <0.05). Conclusion The overexpression of EGFR and VEGF may be related to the occurrence, development and metastasis of breast cancer. It may be of clinical significance to guide chemotherapy, targeted therapy and prognosis.