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目的探讨T2DM患者SUA水平与颈动脉粥样硬化(CAS)的关系。方法纳入T2DM患者1411例,根据有无CAS将其分为颈动脉粥样硬化(A)组和非颈动脉粥样硬化(B)组,比较两组间的临床资料。并以颈动脉内膜-中层厚度(IMT)为因变量,以其他指标为自变量对合并后两组进行Spearman相关分析和Logistic回归分析。结果 A组IMT、SUA、TG水平高于B组(P<0.05)。Logistic回归分析结果显示,SUA水平与IMT增厚相关(r=0.131,OR:1.021,95%CI:1.003~1.205)。结论 T2DM患者SUA水平升高是CAS的独立危险因素。
Objective To investigate the relationship between SUA level and carotid atherosclerosis (CAS) in patients with T2DM. Methods A total of 1411 patients with T2DM were enrolled in this study. The patients were divided into two groups according to their presence or absence of CAS. The patients were divided into two groups: carotid atherosclerosis (A) and non-carotid atherosclerosis (B). The carotid intima - media thickness (IMT) was used as the dependent variable, and other indexes were used as independent variables to analyze Spearman correlation and logistic regression analysis. Results The levels of IMT, SUA and TG in group A were higher than those in group B (P <0.05). Logistic regression analysis showed that SUA levels were associated with IMT thickened (r = 0.131, OR: 1.021, 95% CI: 1.003-1.205). Conclusion The elevated SUA level in T2DM patients is an independent risk factor for CAS.