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目的观察养心通脉片(YTT)对动脉粥样硬化(AS)大鼠痰瘀病机的影响。方法采用高脂饲料喂饲法复制Wistar大鼠AS模型,随机分为三组。YTT组服YTT,绞股蓝总苷片(Met)组服胶股蓝总苷片,模型组不给药,另以正常大鼠为正常组。实验结束后检测血脂、血糖、血液流变学、胰岛素,并作光镜、电镜检测。结果YTT对AS大鼠有明显的降脂效果,能改善血液流变性和胰岛素抵抗,并能消退斑块,维持主动脉组织结构及功能。结论YTT改善AS大鼠痰瘀病机有良好的效果。
Objective To observe the effect of Yangxin Tongmai Tablet (YTT) on the pathogenesis of atherosclerosis (AS) in rats. Methods Wistar rats’ AS models were replicated by high-fat diet and randomly divided into three groups. The YTT group took YTT and the Gynostemma glycoside tablet (Met) group took glucosyl blue glycoside tablets. The model group received no administration, and the normal rats were normal groups. At the end of the experiment, blood lipids, blood glucose, hemorheology, and insulin were measured and examined by light and electron microscopy. RESULTS: YTT had significant lipid-lowering effect on AS rats, improved blood rheology and insulin resistance, and could eliminate plaque and maintain aortic tissue structure and function. Conclusion YTT can improve the morbidity of AS rats.