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目的:探讨选择2个胚胎移植对IVF-ET与ICSI助孕结局的影响。方法:回顾2008年12月～2010年9月在福建省妇幼保健院接受体外受精-胚胎移植(IVF-ET)的494个新鲜周期病例,对3天体外培养胚胎进行全面评级后,各年龄组均选择2个胚胎移植,按含0、1、2个优质胚胎分成3组,比较其对助孕结局的影响。结果:494周期中,2个均为优质胚胎移植的391个周期,占79.14%;含1个优质胚胎移植的74个周期,占15.00%;2个均非优质胚胎移植的29个周期,占5.87%。总的周期妊娠率为40.16%,种植率为25.81%,多胎率为27.27%,其中4例为3胎,50例为双胎。选择2个优质胚胎移植组妊娠率为46.04%,种植率为30.05%,多胎率为29.44%。结论:通过提高优质胚胎选择的准确性,选择2个最优质胚胎移植有助于提高胚胎着床能力和临床妊娠率,获得良好的妊娠结局,但多胎妊娠的发生率并不降低。
Objective: To investigate the effect of two embryos transplantation on IVF-ET and ICSI pregnancy outcomes. Methods: A total of 494 fresh cycles of in vitro fertilization-embryo transfer (IVF-ET) in Fujian Provincial MCH and MCH from December 2008 to September 2010 were reviewed. After three days in vitro culture embryos were graded comprehensively, Two embryos were selected and divided into three groups according to 0, 1 and 2 high quality embryos. The effects on pregnancy outcome were compared. Results: In the 494 cycles, two of them were 391 cycles of high-quality embryo transfer, accounting for 79.14%; 74 cycles of 1 high-quality embryo transfer accounted for 15.00%; 29 cycles of 2 non-high- 5.87%. The total cycle pregnancy rate was 40.16%, the implantation rate was 25.81%, the multiple birth rate was 27.27%, of which 4 were 3 and the other 50 were twins. The pregnancy rate of two high quality embryo transfer groups was 46.04%, the implantation rate was 30.05%, and the multiple birth rate was 29.44%. CONCLUSION: By improving the accuracy of high-quality embryo selection, selecting the two best quality embryos to help improve embryo implantation and clinical pregnancy rates leads to good pregnancy outcome but does not reduce the incidence of multiple pregnancies.