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目的探讨血压盐敏感性和冷加压试验阳性的同胞聚集性。方法通过预筛查和2次血压筛查共纳入163名符合入选条件的先证者和同胞(共68组,49组为2个同胞,19组为3个及以上同胞),对受试者进行慢性盐负荷试验和冷加压(CPT)试验。结果盐敏感者检出率为21.5%,其在3个及以上同胞的同胞对中分布具有聚集性(χ2=19.88,P<0.01);各干预阶段血压变化幅度及尿钠排泄量在同胞间具有显著相关性;冷加压试验阳性检出率为25.15%,其在2,3个及以上同胞的同胞对中分布均具有聚集性(χ2=6.678,P<0.05;χ2=10.615,P<0.05)。冷加压应激后血压变化幅度及恢复时间在同胞间具呈显著相关。结论二项分布分析显示,血压盐敏感性和冷加压试验阳性者在同胞中的分布具有聚集性,表明血压盐敏感性和冷加压试验阳性可能主要由遗传基础决定,而非生活环境影响。
Objective To investigate the blood pressure salt sensitivity and cold compression test positive fellow agglomeration. Methods A total of 163 eligible probands and siblings (68 females in total, 49 females in 2 females and 3 females in 19 females) enrolled in the pre-screening and 2 blood-pressure screening were enrolled. Subjects Chronic salt stress test and cold stress (CPT) test. Results The detection rate of salt sensitivity was 21.5%, which was clustered in sibling pairs of three or more siblings (χ2 = 19.88, P <0.01). The changes of blood pressure and urinary sodium excretion in different interventional stages were (Χ2 = 6.678, P <0.05; χ2 = 10.615, P <0.05). The positive rate of cold-press test was 25.15%, which was clustered in the siblings of 2,3 or more siblings (χ2 = 6.678, 0.05). After the cold stress changes in blood pressure and recovery time in siblings showed a significant correlation. Conclusions The binominal distribution analysis showed that the distribution of blood pressure salt sensitivity and cold-compression test positive in siblings showed aggregation, indicating that the blood pressure salt sensitivity and cold-stress test may be mainly determined by the genetic basis rather than the living environment .