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用原位杂交与组化法观察了水蛭或其复方对实验性动脉粥样硬化家兔主动脉内皮素基因(ET—mRNA)表达的影响。结果表明:喂水蛭或其复方,能改善喂饲高脂饲料家兔内皮功能,减轻内皮细胞损伤,阻止动脉粥样硬化形成,拮抗ET—mRNA在主动脉内膜上过表达,其作用优于绞股蓝总甙。
In situ hybridization and histochemistry were used to observe the effect of leech or its compound on the expression of endothelin gene (ET-mRNA) in experimental atherosclerotic rabbit aorta. The results showed that feeding leeches or its compound can improve the endothelial function of rabbits fed with high-fat diet, reduce the damage of endothelial cells, prevent the formation of atherosclerosis, and antagonize the overexpression of ET-mRNA in aorta intima. Total Gynostemma.