Objective: To study the mechanism of Sini Decoction (SND) in prevention and treatment of post percutaneous transluminal coronary angioplasty (PTCA) ischemia reperfusion injury with different Syndrome typing of TCM.Methods: Forty patients who received PTCA were randomly divided equally into the SND group and the control group, there were 10 of Excess Syndrome (ES) and 10 of Deficiency Syndrome (DS)in each group.25 ml SND was given daily to the SND group from 3 days before operation to the third day after operation. The blood superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) content of patients were determined before PTCA, and 1 hr, 12 hrs, 24 hrs, 48 hrs and 72 hrs after PTCA. Results: Before PTCA, the cases with DS were characterized by low SOD activity and high MDA content, as compared with the patients with ES, P <0.05. SND could relieve the post PTCA deprivation of SOD activity and NO content and the elevation of MDA level in both ES and DS patients, the amplitude of elevation of SOD activity in DS patients was higher than that in ES patients (P<0.05). Conclusion: SND has antagonizing effect on post PTCA ischemia reperfusion injury, which is more effective in treating patients with DS. Objective: To study the mechanism of Sini Decoction (SND) in prevention and treatment of post percutaneous transluminal coronary angioplasty (PTCA) ischemia reperfusion injury with different Syndrome typing of TCM.Methods: Forty patients who received PTCA were randomly divided equally into the SND group And the control group, there were 10 of Excess Syndrome (ES) and 10 of Deficiency Syndrome (DS)in each group.25 ml SND was given daily to the SND group from 3 days before operation to the third day after operation. The blood Superoxide dismutase (SOD) activity, malondialdehyde (MDA) and nitric oxide (NO) content of patients were determined before PTCA, and 1 hr, 12 hrs, 24 hrs, 48 ​​hrs and 72 hrs after PTCA. Results: Before PTCA, the cases With DS were characterized by low SOD activity and high MDA content, as compared with the patients with ES, P <0.05. SND could relieve the post PTCA deprivation of SOD activity and NO content and the elevation of MDA level in both ES and DS pati The ENT, the amplitude of elevation of SOD activity in DS patients was higher than that in ES patients (P<0.05). Conclusion: SND has antagonizing effect on post PTCA ischemia reperfusion injury, which is more effective in treating patients with DS.