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甲苯磺丁脲(D_(860))是治疗非胰岛素依赖型糖尿病的基本药物,其片剂口服后由肠道迅速吸收,降血糖作用较胰岛素持久。甲苯磺丁脲为疏水性药物,在其片剂制备过程中虽然采用大量淀粉做崩解剂,部分片剂崩解时限仍严重不符合药典规定的要求。本实验考察了崩解剂(或助崩剂)种类及用量、片剂硬度、润滑剂用量等对甲苯磺丁脲片崩解时限的影响程度,从而筛选出较为合
Tolbutamide (D_ (860)) is the basic drug for the treatment of non-insulin-dependent diabetes mellitus. Its tablet is rapidly absorbed by the intestine after oral administration, and its hypoglycemic effect is longer than that of insulin. Tolbutamide is a hydrophobic drug. Although a large amount of starch is used as a disintegrant in the process of tablet preparation, the disintegration time limit of some tablets is still not in compliance with the requirements of Pharmacopoeia. This experiment investigated the disintegrating agent (or aiding agent) type and dosage, tablet hardness, lubricants and other dosage of toluene sulfonylurea disintegration time limit, which screened more suitable