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革蓝氏阴性菌丛和葡萄球菌对最广泛用于治疗慢性化脓性支气管炎的抗菌药物的敏感性低,该病的复发率为15～30％(有谓10～76％)。我们于1986年曾报道,用庆大霉素1 mg/kg,每天肌注3次,64％慢性化脓性支气管炎恶化的临床症状于3～6天缓解,支气管内感染的革蓝氏阴性菌和(或)葡萄球菌活性受到抑制。无效的病例,尽管细菌菌株对该药高度敏感,但由于二重感染(以肺炎球菌感染为最多)或混合感染时,抗生素在血液和痰内的浓度低,不足以抑制其中的一种细菌,因而临床症状无改善。当抗生素在血液内或在血液和疾内的含量超过MIC时则
Gram-negative flora and staphylococci are less sensitive to the most widely used antimicrobial agents for the treatment of chronic suppurative bronchitis, with a relapse rate of 15-30% (10- 76%). We reported in 1986 that the clinical symptoms of 64% of chronic suppurative bronchitis were relieved in 3 to 6 days with gentamicin 1 mg / kg intramuscularly 3 times a day, and bronchitis-infected Gram-negative bacteria And / or staphylococcal activity is inhibited. Invalid cases, although bacterial strains are highly susceptible to this drug, the concentration of antibiotics in the blood and sputum is low enough to inhibit one of the two bacteria due to the double infection (with the most pneumococcal infection) or mixed infections, Thus no improvement in clinical symptoms. When antibiotics in the blood or in the blood and disease when the content exceeds the MIC when