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Ⅰ类药物——钠通道阻滞剂 1970年Vaughan Williams提出将抗心律失常药物分为Ⅰ、Ⅱ、Ⅲ和Ⅳ类的方案,1979年Harrison在Vaughen Williams分类方案的基础上又将Ⅰ类药物分为三个亚型,即ⅠA、ⅠB和I C。ⅠA类-奎尼丁、普鲁卡因胺和吡二丙胺等。这类药物延长动作电位时程(APD)和有效不应期(ERP),对V_(max)具中度降低作用。ⅠB类-利多卡因、美西律、妥卡胺和地兰丁(Dilantin)等。这类药物缩短APD和不应期,对V_(max)的降低作用较弱。ⅠC类-恩卡胺、氟卡胺、洛卡胺、Ethmozine和普罗帕酮等。这类药物对V_(max)产生最大降低作用,几乎不改变APD和ERP。
Class I drugs - sodium channel blockers 1970 Vaughan Williams proposed anti-arrhythmic drugs into Ⅰ, Ⅱ, Ⅲ and Ⅳ type of program, Harrison in 1979 Vaughen Williams classification scheme based on the class Ⅰ drugs points Three subtypes, namely IA, IB and IC. Class I A - quinidine, procainamide and pyrrolidine. These drugs extend the action potential duration (APD) and effective refractory period (ERP), V max (max) with a moderate effect. Class IB - lidocaine, mexiletine, metoclopramide and Dilantin, among others. These drugs shorten the APD and refractory period, V_ (max) to reduce the effect is weak. Class I C-enkaamine, flecainide, loralkine, ethmozine and propafenone. These drugs maximally reduce V max, with little change in APD and ERP.