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目的探讨非对称性二甲基精氨酸(ADMA)与急性缺血性脑卒中(CIS)严重程度的关系。方法急性CIS患者266例,分为美国国立卫生研究院卒中评分(NIHSS)评分≤12分组(n=176)和NIHSS评分>12分组(n=90),单因素分析比较2组ADMA、年龄、性别、胆固醇、甘油三酯、体重指数及高血压、糖尿病、吸烟、饮酒患者比例;进行NIHSS评分与上述指标的相关性分析;以CIS患者严重程度(NIHSS评分)为应变量,以单因素分析有统计学意义的变量为自变量,进行多元回归分析,探讨ADMA与CIS严重程度的关系。结果 NIHSS评分>12分组ADMA、胆固醇和甘油三酯均显著高于NIHSS评分≤12分组,差异有统计学意义(均P<0.01)。NIHSS评分与ADMA、胆固醇和甘油三酯均显著正相关(r分别为0.452,0.328,0.275,P均<0.05)。多元回归分析提示ADMA和胆固醇是CIS的独立危险因素。结论 ADMA与NIHSS评分所反映的CIS严重程度正相关。
Objective To investigate the relationship between asymmetric dimethylarginine (ADMA) and the severity of acute ischemic stroke (CIS). Methods Two hundred and sixty-six patients with acute CIS were divided into two groups according to NIHSS score ≤12 (n = 176) and NIHSS score> 12 (n = 90). The ADMA, age, Sex, cholesterol, triglyceride, body mass index and the proportion of patients with hypertension, diabetes, smoking and alcohol drinking. The correlation between NIHSS score and the above indexes was analyzed. According to the severity of CIS (NIHSS score) Statistically significant variables were independent variables and multiple regression analysis to explore the relationship between ADMA and severity of CIS. Results ADMA, cholesterol and triglyceride were significantly higher in NIHSS score> 12 group than those in NIHSS ≤12 group (all P <0.01). The NIHSS score was positively correlated with ADMA, cholesterol and triglyceride (r = 0.452, 0.328 and 0.275, respectively, P <0.05). Multivariate regression analysis suggested that ADMA and cholesterol were independent risk factors for CIS. Conclusion ADMA is positively correlated with the severity of CIS as reflected by the NIHSS score.