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有人提出奥曲肽(生长抑素类似物)可有效地治疗几种胃肠道疾患,但关于它对人胃肠各区段运动功能的作用尚不清楚。本文评估了奥曲肽对健康人胃排空、小肠转运、回结肠固体食物的传递、区段性结肠转运、餐后结肠张力和时相性压力活动的作用。 方法 将12名健康受试者(平均34岁)随机分为两组。受检前晚作肠道准备并禁食,然后吞入~(111)In标记的甲基丙烯树酯胶丸,用γ-相机监测其后胃排空情况。在荧光屏监测下将恒压-测压器联合装置置入降结肠,监测结肠张力和运动,空腹记录40分钟后,一组皮下注射奥
It has been suggested that octreotide (somatostatin analogue) is effective in treating several gastrointestinal disorders, but its role in locomotor function in human gastrointestinal segments is unclear. This article assesses the effects of octreotide on healthy human gastric emptying, intestinal transit, delivery of solid food to the colon, segmental colonic transit, postprandial colonic tone and phase pressure events. Methods Twelve healthy subjects (average 34 years old) were randomly divided into two groups. The intestine was prepared for the night before the test and fasted, and then inoculated with ~ (111) In labeled methyl methacrylate gels, with a gamma camera to monitor the subsequent gastric emptying. Under the fluorescent screen monitor, the constant pressure-manometer combination device was placed into the descending colon to monitor the colon tension and movement. After 40 minutes of fasting recording, a group of subcutaneous injection of Austrian