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Leflunomide,an anti-rheumatoid arthritis drug,controls hyperglycemia by sensitizing insulin receptor
[会议论文] 作者：Xiulong Xu,Michelle E.Doscas,Jin Ye,Ashley J.Williamson,Yanchun Li,Yi Li,
来源：江苏省畜牧兽医学会成立60周年庆典暨2015年学术年会 年份：2015
Leflunomide is an immunosuppressive drug prescribed for treating rheumatoid arthritis(RA).Our recent study showed that A77 1726,the active metabolite of leflunomide,inhibits the activity of p70 S6 kin...
Inhibition of p70 S6 kinase(S6K1)activity induces autophagy through TAK1-mediated AMPK and JNK activ
[会议论文] 作者：Xiulong Xu,Jing Sun,Michelle E.Doscas,Ashley J.Williamson,Ruirong Song,Jingsong Zhou,Jun Sun,Xinan Jiao,
来源：江苏省畜牧兽医学会成立60周年庆典暨2015年学术年会 年份：2015
mTOR activation is known to suppress autophagy by phosphorylating ULK1 at S757 and deactivating its enzymatic activity.Here we report that feedback activation of the mTOR-PI3K pathway by two S6K1 inhi...
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