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[会议论文] 作者：Huchen Zhou,
来源：2015年全国药物化学学术会议暨第五届中英药物化学学术会议 年份：2015
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[会议论文] 作者：Huchen Zhou,
来源：2013第六届世界癌症大会 年份：2013
As the best-characterized ubiquitin-like protein (UBL), small ubiquitin-related modifier (SUMO) was found to conjugate with a number of proteins to regulate cellular functions including transcription,...
[会议论文] 作者：Mingyan Zhu,Seung Bum Park,Huchen Zhou,
来源：The 24th International Society of Heterocyclic Chemistry Con 年份：2013
We synthesized benzopyran embedded drug-like and natural product-like compounds through diversity-oriented and combinatorial synthesis.[1] According to their bi...
Identification of SENP1 inhibitors with novel scaffolds through in silico screening and rational dru
[会议论文] 作者：Yaxue Zhao,Zhongli Wang,Jianchen Zhang,Huchen Zhou,
来源：第十三届全国计算机化学学会会议 年份：2015
The small ubiquitin-related modifier(SUMO)-specific proteases(SENPs)catalyze the maturation of SUMO precursors(pre-SUMOs)and deconjugation of SUMO from thei...
[会议论文] 作者：Jiong Zhang,Long Ye,Dazhong Ding,Huchen Zhou,
来源：中国化学会第十届全国化学生物学学术会议 年份：2017
An interesting class of cyclic boron-containing compounds,benzoxaboroles,were first synthesized in 19571 while its medicinal usage had remained unexplored for fifty years until tavaborole(Kerydin)(Fig...
Design,Synthesis,and Biological Evaluation of Benzodiazepine-Based SUMO-Specific Protease 1 Inhibito
[会议论文] 作者：Weiwei Wang,Lie Wang,Yaxue Zhao,Zhitao Qiao,Huchen Zhou,
来源：第九届IUPAC化学生物学国际研讨会暨第八届世界华人药物化学研讨会 年份：2012
SUMO(small ubiquitin-related modifier) was found to conjugate with a number of proteins to regulate cellular functions including transcription,signal transduction,and cell cycle.SUMO-specific protease...
Small molecule targeting Cdc42-intersectin interaction disrupts Golgi organization and suppresses ce
[会议论文] 作者：Yaxue Zhao,Amy Friesland,Yan-Hua Chen,Lie Wang,Qun Lu,Huchen Zhou,
来源：第十二届全国计算(机)化学学术会议 年份：2013
Signaling through the Rho family of small GTPases has been intensely investigated for its crucial roles in a wide variety of human diseases.1 Although RhoA and Racl signaling pathways are frequently e...
[会议论文] 作者：Chunmin Ma,Lili Song,Jiong Zhang,Hanzhang Xu,Yingli Wu,Hu Lei,Huchen Zhou,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
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[会议论文] 作者：Chunmin Ma,Lili Song,Jiong Zhang,Hanzhang Xu,Huchen Zhou,Yingli Wu,Hu Lei,
来源：中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 年份：2014
Non-Hodgkins lymphoma (NHL) is a heterogeneous class of cancers.Even though completeresponse rates of 40-50％ with chemotherapy can be attained, a substantial proportionof patients relapse, resulting i...
[会议论文] 作者：Yaxue Zhao,Dazhong Ding,Guangwei Gao,Qingqing Meng,Femando Rock,Dickon Alley,Jake Plattner,Dawei Li,Huchen Zhou,
来源：第八届全国化学生物学学术会议 年份：2013
The protozoan parasite Trypanosoma brucei (T.brucei) causes human African trypanosomiasis (HAT) which is also known as sleeping sickness.It is a neglected fatal disease and continues to pose a major t...
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