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[会议论文] 作者:Xingxu Huang,
来源:第三届上海科技大学免疫化学国际生物论坛 年份:2016
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[期刊论文] 作者:Yao LIU,Xingxu HUANG,Xiaolong WANG,
来源:农业科学与工程前沿(英文版) 年份:2020
Genome editing based on CRISPR/Cas9 system enables unprecedented breakthroughs in genomic research and the engineering of variants associated to clinical diseas...
Mitotic chromosome mis-segregation mediated by Separase phosphosite mutation leads to aneuploidy and
[会议论文] 作者:Xingxu Huang,Meizhi Wang,Jingmei Chen,
来源:第十一次中国生物物理学术大会 年份:2009
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[会议论文] 作者:Xingxu Huang,Weizhi Ji,Jiahao Sha,
来源:第三届全国发育生物学大会 年份:2016
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Mitotic chromosome mis-segregation mediated by Separase phosphosite mutation leads to aneuploidy and
[会议论文] 作者:Xingxu Huang,Meizhi Wang,Jingmei Chen,
来源:第十一次中国生物物理学术大会 年份:2009
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[期刊论文] 作者:Shaoshuai Mao,Yajing Liu,Shisheng Huang,Xingxu Huang,Tian Chi,
来源:遗传学报 年份:2019
Site-directed RNA editing (SDRE) is invaluable to basic research and clinical applications and has emerged as a new frontier in genome editing.The past few year...
[会议论文] 作者:Yu Kang,Bo Zheng,Bin Shen,Yongchang Chen,Jiahao Sha,Weizhi Ji,Xingxu Huang,
来源:第三届全国发育生物学大会 年份:2016
Mutations in the DAX1 locus cause X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism (HH),which manifest with primary adrenal insufficiency and incomplete or absent sexual m...
[会议论文] 作者:Yuanwu Ma,Wei Chen,Xu Zhang,Lei Yu,Wei Dong,Shuo Pan,Shan Gao,Xingxu Huang,Lianfeng Zhang,
来源:第十二届中国实验动物科学年会 年份:2016
Precise modifications such as site mutation,codon replacement,insertion or precise targeted deletion are needed for studies of accurate gene function.The CRISPR/Cas9 system has been proved as a powerf...
[会议论文] 作者:Jiajie Hou,Yongxiang Xia,Runqiu Jiang,Dianyu Chen,Juan Xu,Lei Deng,Xingxu Huang,Xuehao Wang,Beicheng,
来源:2013中国器官移植大会 年份:2013
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[会议论文] 作者:Yuanwu Ma,Lianfeng Zhang,Jing Ma,Xu Zhang,Wei Chen,Lei Yu,Yingdong Lu,Lin Bai,Bin Shen,Xingxu Huang,
来源:2014第十一届中国实验动物科学年会 年份:2014
The type Ⅱ bacterial CRISPR/Cas system is a very valuable genome-engineering tool, which has been widely used in genome editing of variety of organisms.Previously, we generated the floxed alleles in r...
[期刊论文] 作者:Yao Liu,Guang Yang,Shuhong Huang,Xiangyang Li,Xin Wang,Guanglei Li,Tian Chi,Yulin Chen,Xingxu Huang,Xiaolong,
来源:细胞研究(英文版) 年份:2021
Dear Editor,rnThe most advanced prime editor 3 (PE3) system comprises the editor,a fusion protein of Cas9 H840A nickase and mutant reverse transcriptase (RTase) (hereafter termed NMRT),a prime editing guide RNA (pegRNA) and an alternative s......
[期刊论文] 作者:Li,Yajing Liu,Yanting Zeng,Jianan Li,Lijie Wang,Guang Yang,Dunjin Chen,Xiaoyun Shang,Jia Chen,Xingxu Huang,
来源:蛋白质与细胞 年份:2017
Dear Editor,CRISPR/Cas9 is a powerful tool for genome editing (Komor et al.,2017).Recently,it has been employed in several attempts to edit the human embryos (L...
Efficient Generation of Gene-Modified Pigs HarboringPrecise Orthologous Human Mutation via CRISPRCas
[会议论文] 作者:Xiaoyang Zhou,Lulu Wang,Yinan Du,Fei Xie,Liang Li,Yu Liu,Chuanhong Liu,Shiqiang Wang,Shibing Zhang,Xingxu Huang,
来源:第十二届中国实验动物科学年会 年份:2016
Precise genetic mutation of model animals is highly valuable for functional investigation of human mutations.Clustered regularly interspaced short palindrom...
Efficient Generation of Gene-Modified Pigs Harboring Precise Orthologous Human Mutation via CRISPRCa
[会议论文] 作者:Xiaoyang Zhou,Lulu Wang,Yinan Du,Fei Xie,Liang Li,Yu Liu,Chuanhong Liu,Shiqiang Wang,Shibing Zhang,Xingxu Huang,
来源:第十二届中国实验动物科学年会 年份:2016
Precise generic mutation of model animals is highly valuable for functional investigation of human mutations.Clustered regularly interspaced short palin-dro...
GGPP-mediated protein geranylgeranylation in oocyte is essential for the establishment of oocyte-gra
[会议论文] 作者:Diao,Yong-Juan Sang,Rui-Lou Zhu,Na Xu,Xiu-Xing Wang,Zhong Chen,Wei-Wei Tao,Bing Yao,Hai-Xiang Sun,Xingxu Huang,
来源:第三届全国发育生物学大会 年份:2016
The primary-secondary follicle transition,which is essential to provide ova for later reproductive life,requires the bidirectional communication between the...
[期刊论文] 作者:尹亚飞,颜丕熙,Jinlong Lu,Guang Song,Yangyang Zhu,Zhaohui Li,Bin Shen,Xingxu Huang,Heng Zhu,Stuart H.Orkin,沈晓骅,
来源:科学新闻 年份:2016
文章简介长链非编码RNA(lncRNA)是一类长度大于200nt且不编码蛋白质的RNA转录物。近年来,随着高通量测序的普及越来越多的lncRNA被鉴定出来,据估算人和小鼠的基因组中lncRNA...
[会议论文] 作者:Xiaoyang Zhou,Jian Li,Yu Liu,Jianying Wang,Jiankui Zhou,Bian Hu,Nannan Kang,Jimin Gao,Liqing Yu,Xingxu Huang,
来源:2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会 年份:2016
Co-injection of zygotes with Cas9 mRNA and sgRNA has been proven to be an efficient gene-editing strategy for genome modification of different species.Genetic engineering in pigs holds a great promise...
Production of Human Albumin in Pigs Through CRISPR/Cas9-Mediated Knockin of Human cDNA into Swine Al
[会议论文] 作者:Junyi Jiang,Xiaoyang Zhou,Lei Song,Lulu Wang,Chen Ding,Jun Qin,Liping Liu,Weihua Wang,Jianqiao Liu,Xingxu Huang,
来源:2016华南实验动物科学国际研讨会、第三届实验小型猪国际论坛暨广东·九州实验动物学术交流会 年份:2016
Precise genome modifcation in large domesticated animals is desirable under many circumstances.In the past it is only possible through lengthy and burdensome cloning procedures.Here we attempted to ac...
SARS-CoV-2 nucleocapsid protein phase separates with G3BPs to disassemble stress granules and facili
[期刊论文] 作者:Ma,Boxing Jin,Yulin Zhou,Su He,Jinhua Huang,Xun Xu,Yan Zou,Ping Li,Aibin Liang,Jia Liu,Tian Chi,Xingxu Huang,
来源:科学通报(英文版) 年份:2021
A key to tackling the coronavirus disease 2019 (COVID-19) pandemic is to understand how severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) manages to outsmart host antiviral defense mecha-nisms.Stress granules (SGs),which are asse......
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