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Application of population pharmacokinetic modeling in clinical development of a novel PPI CPRCX: com
[会议论文] 作者：Xuemei Liu,Hongyun Wang,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
CPRCX is a novel investigated proton pump inhibitor, which shows dramatic success in the management of acid-related disorders.Now this drug is being developed in Phase Ⅱ study in China.In this paper f...
Population pharmacokinetic pharmacodynamics model for PEGylated human growth hormone in healthy subj
[会议论文] 作者：Xin Zheng,Xia Chen,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Background: Growth hormone deficiency (GHD) in paediatric and adult patients so currently necessitates long-term treatment and persistence with a daily s.c injection regimen.Taking the low compliance...
Predictions about probabilities of adverse events and appropriate dose of roflumilast for Chinese CO
[会议论文] 作者：Xinge Cui,Xin Zheng,Pei Hu,Ji Jiang,
来源：第五届定量药理学与新药评价国际会议 年份：2015
Backgrounds: Roflumilast is an oral inhibitor of phosphodiesterase 4(PDE4), which is mainly metabolized by CYP3A4 and CYP1A2.The main metabolite of it is roflumilast N-oxide, which contributes to the...
,Evaluating a physiologically based pharmacokinetic model for predicting the pharmacokinetics of mid
[期刊论文] 作者：Hong-yun WANG,Xia CHEN,Ji JIANG,Jun SHI,Pei HU,
来源：中国药理学报（英文版） 年份：2016
...
OBSERVATIONS OF PLASMA ARGININE,ADMA AND SDMA CONCENTRATIONS IN RELATION TO RENAL FUNCTION IN BURN P
[会议论文] 作者：Hongyun WANG,Ji JIANG,Pei HU,Yongming YU,Ronald G.TOMPKINS,
来源：2009第十三届北京分析测试学术报告会 年份：2009
...
Predicting whole blood concentrations of zonisamide in human using a physiologically based pharmacok
[会议论文] 作者：Xin Zheng,Kairui Feng,Pei Hu,Ji Jiang,Jun Shi,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium 年份：2013
...
A novel MOF with double helical chains based rigid tripodal ligands syntheses,crystal structures,and
[会议论文] 作者：Xiao Wang,Xiang Yang Hou,Ji Jiang Wang,Feng Fu,
来源：2016年中西部地区无机化学化工学术研讨会 年份：2016
A three-dimensional metal-organic framework (MOF),namely [Cd2(BPDB)2(H2O)]n (1) (2,6-di-p-carboxyphenyl 4,4-bipyridine1=H2bpydb) has been solvothermal synth...
OBSERVATIONS OF PLASMA ARGININE,ADMA AND SDMA CONCENTRATIONS IN RELATION TO RENAL FUNCTION IN BURN P
[会议论文] 作者：Hongyun WANG,Ji JIANG,Pei HU,Yongming YU,Ronald G.TOMPKINS,
来源：2009第十三届北京分析测试学术报告会 年份：2009
...
A novel MOF with double helical chains based rigid tripodal ligands: syntheses,crystal structures,an
[会议论文] 作者：Xiao Wang,Xiang Yang Hou,Ji Jiang Wang,Feng Fu,
来源：2016年中西部地区无机化学化工学术研讨会 年份：2016
A three-dimensional metal-organic framework (MOF),namely [Cd2(BPDB)2(H2O)]n (1) (2,6-di-p-carboxyphenyl 4,4'-bipyridine1=H2bpydb) has been solvothermal synt...
Development and validation a PBPK model to predict age-dependent PK for Chinese subjects-a case stud
[会议论文] 作者：Hongyun Wang,Xia Chen,Jun Shi,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Aim:Todevelop and validate a general physiologicallybased pharmacokinetic (PBPK) model for hepatic pathway in Chinese adults at various ages, and to evaluate it with midazolam (substrate of CYP3A4) as...
[会议论文] 作者：Jia Chen,Dongyang Liu,Qian Zhao,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:Icotinib is a potent small-molecule inhibitor of epidermal growth factor receptor (EGFR)-tyrosine kinase (TKI), which was designed for the treatment of non-small cell lung cancer (NSCLC).It...
A semi-mechanistic population pharmacokinetic model describing the time-dependent kinetics of Red Bl
[会议论文] 作者：Kairui Feng,Xin Zheng,Wenyuan Qi,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background: XQ (Carfree, Nanjing, China), a new chemical entity that possesses pharmacological activity on PlateletActivating Factor (PAF).XQ was approved into phase Ⅰ evaluation for treatment of isch...
A Mechanistic Pharmacokinetic-Pharmacodynamic Model for the Effect of Esomeprazole in Healthy Subjec
[会议论文] 作者：Dongyang Liu,Hong Yang,Jiaming Qian,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Esomeprazole has proved to be effective for the treatment of gastroesophogeal reflux disease (GERD) and ulcers, where intra-gastric pH value is a biomarker to indicate esomeprazole effects on these di...
Population pharmacokinetic/pharmacodynamic Modeling for Pegylated Recombinant Human Growth Hormone (
[会议论文] 作者：Xin Zheng,Tao Liu,Qian Zhao,Pei Hu,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:CPRC-Y is a pegylatedrecombinant human growth hormone (rhGH) developed with the aim of reducing serum clearance and thereby prolonging the exposure leading to once-weekly sc administration.T...
Predicting whole blood concentrations of zonisamide in human using a physiologically based pharmacok
[会议论文] 作者：Xin Zheng,Kairui Feng,Pei Hu,Jun Shi,Ji Jiang,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Background:Concentration dependent Blood to plasma ratio (B/P) of zonisamide(ZNS) was observed in clinical trial, which requires measuring both plasma concentration and whole blood concentration for c...
[会议论文] 作者：Rui Chen,Dongyang Liu,Jun Shi,Ji Jiang,Pei Hu,
来源：第四届定量药理学与新药评价国际会议·2013(The 4th International Symposium in Qu 年份：2013
Objective:In vitro information on dextromethorphan (DXM) and the Advanced Dissolution Absorption Metabolism (ADAM) model, incorporated into PBPK simulator Simcyp(@) (v.12) were used to investigate dif...
[会议论文] 作者：Fu Xiaoping,Zhang Xiaohua,Yan Xin,Liu Ji,Jiang Hongxia,
来源：2012全国临床微生物与感染免疫学术研讨会 年份：2012
The main objective of this study was to characterize the molecular characterization of ciprofloxacin-resistant salmonella and the relationship between virulence and resistance of these strains isolate...
[期刊论文] 作者：Xuerui Wang,Ji Jiang,Dezhong Liu,Youquan Xue,Chun Zhang,Xuehong Gu,,
来源：Chinese Journal of Chemical Engineering 年份：2017
This work presents the design of hollow fiber T-type zeolite membrane modules with different geometric configurations. The module performances were evaluated by...
[期刊论文] 作者：Wei Dai,Song-bai Xue,Feng Ji,Jiang Lou,Bo Sun,Shui-qing Wang,,
来源：International Journal of Minerals Metallurgy and Materials 年份：2013
Al-6.5Si-42Zn and Al-6.5Si-42Zn-0.09Sr filler metals were used for brazing 6061 aluminum alloy. Air cooling and water cooling were applied after brazing. Si pha...
[期刊论文] 作者：Chunkui Zhou,Limin Wu,Fengming Ni,Wei Ji,Jiang Wu,Hongliang Zhang,,
来源：Neural Regeneration Research 年份：2014
Critical illness polyneuropathy and critical illness myopathy are frequent complications of severe illness that involve sensorimotor axons and skeletal muscles,...
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