OCCLUDIN相关论文
目的 探讨醒脾胶囊通过血管活性肠肽（VIP）修复肠道屏障且调节RhoA/ROCK2信号通路抑制肠道运动亢进，缓解功能性腹泻（FDr）脾虚证的作用机......
紧密连接蛋白不仅是维持上皮屏障功能的重要蛋白，更是多种病毒感染细胞的受体与辅助分子。为了明确紧密连接主要组成蛋白occludin和......
目的:观察丹参总酚酸通过调控紧密连接蛋白ZO-1、occludin表达对慢性肾衰竭大鼠肾脏纤维化的作用。方法:将120只大鼠分为正常组（Nor......
丙型肝炎病毒（HCV）感染仍然是一个非常严重的全球性公共卫生问题,数千万慢性HCV感染者面临罹患肝癌的风险。尽管直接作用抗病毒药物......
随着益生菌益生作用的不断发现并被报道,加之其应用优势,越来越多的益生菌被用于研究它们对肠道疾病的改善作用。本实验室早期从大......
目的 探讨益景汤对糖尿病(DM)大鼠血-视网膜屏障(BRB)的保护效应及机制.方法 45只大鼠被随机分为3组:正常组、糖尿病组(DM组)、益......
研究背景和目的:紧密连接蛋白是存在于上皮细胞与内皮细胞之间的一种蛋白质,其作用是保持细胞间结构的完整性。OCCLUDIN蛋白作为紧......
目的:研究红景天苷(Sal)对实验性脓毒症大鼠脑水肿的影响及分子机制.方法:经股静脉注射脂多糖(LPS)制备大鼠脓毒症模型,红景天苷治......
目的 探讨紧密连接蛋白家族成员Occludin(OCLN)在膀胱癌中的表达情况及调控膀胱癌细胞自噬的机制和临床意义.方法 (1)分析膀胱癌中......
Modified Da-chai-hu Decoction regulates the expression of occludin and NF-κB to alleviate organ inju
Modified Da-chai-hu Decoction (MDD),a traditional Chinese medicinal formulation,which was empirically generated from Da-......
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Emodin promoted pancreatic claudin-5 and occludin expression in experimental acute pancreatitis rats
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Aims To investigate the effects of Lactosucrose on intestinal barrier in TNBS-Induced rats.Methods Lactosucrose were adm......
Effect of Ala-Gln on the localization and expression of tight junction(TJ)protein occludin of IPEC-1
The objective of the present study was to determine effects of dietary Ala-Gln supplementation on intestinal barrier per......
The exogenous estradiol and progesterone induced E-cadherin and Occludin expression in ovine oviduct
We firstly found the expression of E-cadherin and Occludinin ovine oviduct and the expression was different in oestrous ......
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Propofol attenuated TNF-α-modulated occludin expression by inhibiting HIF-1α/VEGF/VEGFR-2/ERK signal
目的 The levels of tight junction proteins(TJs),especially occludin correlate with blood-brain barrier(BBB)disruption ca......
紧密连接蛋白主要位于上皮细胞近管腔的侧面，其功能是封闭细胞间隙，阻止管腔上皮层内外物质的自由进出，是上皮细胞选择通透作用的物质......
Cerebral ischemia-induced occludin degradation promotes blood brain barrier endothelial cell apoptos
Intracerebral hemorrhage is the most dangerous complication in tPA thrombolytic therapy for ischemic stroke,which occurs......
Blood cleaved occludin:an early biomarker predictive of intracerebral hemorrhage associated tPA thro
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The γ-secretase blocker reduces the permeability of the blood-brain barrier by decreasing the ubiqui
Aim: Cerebral ischemia/reperfusion injury induces alterations in many signaling pathways that underlie BBB disruption an......
The process in which new vessels grow from an existed vessel is named angiogenesis.Angiogenesis plays an important role ......
Breakdown of the Gut Barrier in Patients with Multiple Organ Dysfunction Syndrome Is Attenuated By C
Background.Breakdown of the gut barrier increases intestinal permeability and allows movement of intraluminal contents a......
目的：探讨凝血酶对体外培养的人脐静脉血管内皮细胞通透性的影响作用。方法：不同浓度凝血酶作用体外培养的人脐静脉内皮细胞,细胞动......
目的：通过建立脑出血(ICH)动物模型,研究7.5％高渗盐水治疗脑出血所致脑水肿的效果及对血脑屏障通透性的影响,并进一步探讨7.5％高渗盐......
目的：观察Lieber-DeCarli酒精饲料喂养6周诱导的慢性酒精性肝损伤模型大鼠小肠紧密连接的改变,并从肌球蛋白轻链激酶依赖途径探讨其......
目的 研究局灶性脑缺血/再灌注损伤大鼠脑组织病理变化及脑组织水通道蛋白4 (AQP4)和相关蛋白表达变化,以探索AQP4与脑水肿的关系.......
Effects of Low Level Lead Exposure on Brain Barriers: Role of Activation of Nonreceptor Tyrosine Kin
Background Lead (Pb), as a widespread enviromnental pollutant, is known to cause a wide range of neurotoxic effects, inc......
Preeclampsia umbilical cord serum-induced changes in tight junction morphology and occludin expressi
Objective To investigate preeclampsia umbilical cord serum-induced changes in the morphology of tight junction and the e......
目的：探讨白芍总苷(TGP)对葡聚糖硫酸钠(DSS)诱导的溃疡性结肠炎(UC)小鼠模型肠黏膜occludin、MFG-E8 表达的影响。方法：BALB/c 小鼠......
牛病毒性腹泻病毒(Bovine viral diarrhea virus，BVDV)感染引起的牛、羊、猪、鹿等动物接触性传染病。BVDV感染引起感染动物出现高......
目的 研究Sirt1和连接蛋白在银屑病皮损中的表达,以及Sirt1的异常表达与活化对体外培养的人永生化角质形成细胞株(HaCaT细胞)连接......
目的研究Sirt1和连接蛋白在银屑病皮损中的表达,以及Sirt1的异常表达与活化对体外培养的人永生化角质形成细胞株(HaCaT细胞)连接蛋......
Chlorogenic acid,a natural phenolic acid present in fruits and plants,provides beneficial effects for human health.T......
目的:观察四君子汤对2,4,6-三硝基苯磺酸(TNBS)诱导的溃疡性结肠炎大鼠治疗作用及其对黏膜上皮细胞紧密连接蛋白闭合蛋白(Occludin......
目的 探讨氟伐他汀对大鼠脑缺血再灌注后缺血侧皮质区claudin-5和occludin表达的影响.方法 成年雄性SD大鼠随机分为假手术组、模型......
目的 研究紧密连接蛋白occludin在急性白血病(acute leukemia, AL)患者中的表达水平,探讨occludin蛋白在AL预后中的意义.方法 ......
目的观察紧密连接蛋白在高尿酸血症致大鼠肾损害模型中的表达变化以及非布司他的干预疗效。方法将SD大鼠分为正常组,高尿酸血症组(......
本试验旨在研究珍珠龙胆石斑鱼(Epinephelus fuscoguttatus♀×Epinephelus lanceolatus)闭锁小带蛋白-1(ZO-1)、闭锁蛋白(Occludi......
目的:体外分析occludin在紧密连接中的作用。方法:构建RNA干扰慢病毒载体,转染TM4细胞后,用RT-PCR和Western blot检测其对occuldin......
Large deletions within the spinal muscular atrophy gene region in a patient with spinal muscular atr
Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disorder characterized by degeneration and loss of......
