Peptidase相关论文
Molecular mechanism study and overcome of rice hybrid male sterility using CRISPR/Cas9-based editing
Manipulation of male fertility is essential for heterosis utilization in crop production.Heterosis utilization is an eff......
Hepatitis C virus(HCV)is a major cause of chronic liver diseases,including steatosis,cirrhosis and hepatocellular carcin......
The enzyme, dipeptidyl peptidase Ⅳ(DPP Ⅳ), is a novel target for the treatment of type 2 diabetes. Dipeptidyl peptidas......
Pathophysiological mechanisms involved in non-alcoholic steatohepatitis and novel potential therapeu
Non-alcoholic fatty liver disease(NAFLD) is a major health care problem and represents the hepatic expression of the met......
Expression and Characterization of a Thermostable Acyl-peptide Releasing Enzyme ST0779 from Sulfolob
Acyl-peptide releasing enzyme(AARE) belongs to a serine peptidase family and catalyzes the NH2-terminal hydrolysis of N......
Thirteen thiomorpholine-bearing compounds were designed and synthesized as dipeptidyl peptidase IV(DPP-IV) inhibitors, w......
Type 2 diabetes mellitus is emerging as a new clinical problem within pediatric practice.Recent reports indicate an incr......
Dipeptidyl peptidase Ⅳ(DPP4) inhibitors are proven in the treatment of type 2 diabetes.We designed and synthesized a se......
Efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with diabete
AIM:To assess the efficacy and safety of vildagliptin/pioglitazone combination therapy in Korean patients with type 2 di......
The addition of the dipeptidyl peptidase-4 (DDP-4) inhibitor has been reported to achieve greater improvements in glucos......
Pharmacological inhibition of diacylglycerol acyltransferase-1 and insights into postprandial gut pe
AIM To examine the role that enzyme Acyl-CoA:diacylglycerol acyltransferase-1(DGAT1) plays in postprandial gut peptide s......
AIM: To assess the efficacy and safety of vildagliptin 50 mg bid as add-on therapy to insulin in Asian patients with typ......
AIM:To investigate efficacy and safety of vildagliptin compared to other oral antidiabetics in clinical practice in Germ......
胰高血糖素样肽-1(glucagon-like peptide-1,GLP-1)是一种重要的肠促胰素,除了血糖控制作用外,近年来大量研究证实它还能增加胰岛......
AIM: To investigate the presence and potency of natural enzyme inhibitors with hypoglycemic potentials amongst Eucalyptu......
Ischemic stroke is a leading cause of mortality and long-term disability worldwide. Given the detrimental effects of acu......
There are many advantages of combining incretin therapy[glucagon-like peptide-1(GLP-1)receptor agonists and dipeptidyl p......
Incretin-based therapies have revolutionized the medical management of type 2 diabetes mellitus(T2DM) in the 21 st centu......
Type 2 diabetes mellitus and Alzheimer’s disease are both associated with increasing age,and each increases the risk of......
Long-acting glucagon-like peptide-1(GLP-1) analogues marketed for type 2 diabetes(T2D) treatment have been showing posit......
Prediction of the effect on antihyperglycaemic action of sitagliptin by plasma active form glucagon-
AIM: To investigate whether active glucagon-like peptide-1(GLP-1) is a prediction Factor of Effect of sitagliptin on pat......
Risk of pancreatic adverse events associated with the use of glucagon-like peptide-1 receptor agonis
AIM: To systematically assess risk of pancreatic adverse events with glucagon-like peptide-1(GLP-1) receptor agonist and......
二肽基肽酶Ⅲ(dipeptidyl peptidaseⅢ,DPPⅢ)可裂解3~10个氨基酸长度多肽N末端的二肽残基,并通过分解某些寡肽或其片段参与病理生......
Low expression of angiotensinogen and dipeptidyl peptidase 1 in saliva of patients with proliferativ
AIM To elucidate the profile of the salivary proteome.METHODS Unstimulated whole mouth saliva was collected from 30 volu......
Chronic low vitamin intake potentiates cisplatin-induced intestinal epithelial cell apoptosis in WNI
AIM:To investigate if cisplatin alters vitamin status andif VR modulates cisplatin induced intestinal apoptosis andoxid......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
阜阳市局 ￡4a 局长——_MINtkMMtgj’＃lnH＄B——q.M——D收束志不他只邀狲位J则【科校为先导推动地租工作.B为广为戳民U用凶盼引眯B.......
Review on the Effect of Glucagon-Like Peptide-1 Receptor Agonists and Dipeptidyl Peptidase-4 Inhibit
Non-alcoholic fatty liver disease(NAFLD) is a common liver disease and it represents the hepatic manifestation of metabo......
To study the structure-activity relationship of endomorphins (EMs), the action of opioid receptor binding (AORB), analge......
Aim:To investigate the role of a novel dipeptidyl peptidase 8 transcript variant(DPP8-v3)gene in testis developmentand/......
Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B an
AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Morris......
研究背景:近日美国食品药品管理局(FDA)根据SAVOR-TIMI 53和EXAMINE两项大型临床研究的安全审查结果,就沙格列汀、阿格列汀以及含......
The outbreak of Streptococcus suis re-cently in some districts of Sichuan Province in China has caused over 30 deaths an......
Diabetes mellitus(DM) is a major risk factor for cardiovascular events, including ischemic stroke. Moreover, ischemic st......
AIM To study the effects of linagliptin on the structural signs of non-alcoholic fatty liver disease(NAFLD) in db/db mic......
Irradiation Injury Temporarily Induces Enhancement of APN/CD13 Peptidase Activity on Aorta-gonads-me
This study was designed to investigate the expression of aminopeptidase N (APN)/CD13 on intraembryonic AGM stromal cells......
Anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV a
Objective: To evaluate the anti-diabetic potential of leaf extract from Urena lobata(U. lobata) through dipeptidyl pepti......
AIM:To investigate the mechanism and in vivo effects of MK-0626,a dipeptidyl peptidase-4 inhibitor,on hepatic steatosis ......
Peptidomimetics with three types, as the structural or functional mimetics of natural active peptides, can preserve the ......
本文报道了在合成天然的蛋白酶体抑制剂Syringolin A(SylA)及其类似物的过程中,首先合成的两种类型的SylA开环类似物。经过7步反应......
美国FDA于2011年5月2日批准Tradjenta片剂(有效成分为linagliptin)治疗成人2型糖尿病,主要用于结合饮食和运动改善病人对血糖水平......
The defect of TPP Ⅰ causes a disease, late infantile neuronal ceroid lipofuscinosis(LINCL, CLN2). To investigate the bi......
β细胞胰岛素分泌缺陷和α细胞胰高糖素不适当的分泌增加是2型糖尿病发病和进展的重要原因.二肽基肽酶Ⅳ(dipeptidyl-peptidaseⅣ,......
Effect of Urena lobataleaves extract on glucagon like peptide-1 serum level by inhibition of dipepti
OBJECTIVE To investigate effect of Urenalobataleaves extract on glucagon like peptide-1(GLP-1)serum level by inhibition ......
Effect of Calcium Cation on Thermophilic Acylamino Acid-releasing Enzyme Ape1547 from Aeropyrum pern
The gene of enzyme(Ape1547) was cloned from hyperthermophilic archaeon Aeropyrum pernix K1 and expressed in Escherichia ......
Prolyl oligopeptidase (POP) is a cytosolic enzyme involved in the metabolism of many peptide hormones and neuropeptides ......
RECOGNITION SEQUENCE SPECIFICITY OF SIGNAL PEPTIDASE I AND THE ROLE OF SIGNAL PEPTIDE IN SECRETION O
By recombinant DNA technology, the N-terminal of the β-protein encoding region of plasmid pUBHO is fused with the struc......
