poloxamer相关论文
Enhanced Immune Response of Foot-and-mouth disease Type O Polypeptide Vaccine Using Poloxamer Adjuva
Poloxamer is a thermosensitive polymer that exhibits solution–gel transformation as the temperature increases.The curre......
OBJECTIVE To prepare thermosensitive ocular gel of Qingkailing (QKLTOG) with orthogonal design method, determine the opt......
Influence of Poloxamer Composition on the Properties of Thermosensitive in Situ Hydrogel for Vaginal
To investigate the influence of formular composition on the in vitro and in vivo properties of poloxamer-based thermosen......
A Poloxamer Based in situ Eye Gel for an Easy and Prolonged Application of Basic Fibroblast Growth F
Basic Fibroblast Growth Factor (bFGF) is a cytokine that plays an important role in cell proliferation,tissue developmen......
Evaluation of pluronic nanosuspensions loading a novel insoluble anticancer drug both in vitro and i
Aim: The aim of this study was to prepare a nanosuspension loading a novel insoluble anticancer drug (Q39) by precipitat......
The electrochemical method to predict the antibacterial activity of quaternary chitosan in aqueous s
Purpose.Quaternary chitosan is a well-known antimicrobial agent.It is biocompatible,biodegradable and environmental-......
以自由基溶液聚合方法制备了聚(甲基丙烯酸-co-泊洛沙姆)共聚物水凝胶,研究凝胶的溶胀和模型药物氢溴酸右美沙芬(DMP)和维生素B12......
应用溶剂-熔融法将葛根大豆甙元与载体poloxamer制成不同比例的共沉淀物以提高药物的溶出速度。采用差热分析和热台显微镜技术,测......
酮基布洛芬是一有效的非甾体消炎药,常用于治疗各种急、慢性关节炎。与其它非甾体抗炎药一样,酮基布洛芬口服可产生一系列严重的......
目的制备氯雷他定温敏型鼻用凝胶并考察其质量。方法采用包合技术制备氯雷他定和羟丙基-β-环糊精包合物,再与不同配方的泊洛沙姆......
使用熔融法制备利多卡因-泊洛沙姆固体分散体以提高利多卡因的溶解度及溶出度.以利多卡因(LIC)作为模型药物,分别使用泊洛沙姆188(......
目的:制备硝酸毛果芸香碱(PN)温敏型眼用脂质体凝胶,并对其体外释放行为进行考察。方法:将PN脂质体分散于温敏基质泊洛沙姆407(P40......
目的制备一种具有生物黏附性的双氯芬酸温度敏感水凝胶用于眼部局部给药,以提高其生物利用度。方法选用泊洛沙姆F-127(pluronic F-......
目的 筛选用于治疗近视的复方甲硫酸新斯的明眼用原位凝胶处方.方法 温度敏感型凝胶以泊洛沙姆P407和泊洛沙姆P188为基质;离子敏感......
A dense graphene monolith with poloxamer prefunctionalization enabling aqueous redispersion to obtai
The realization of good aqueous dispersibility of commercial graphene products composed of exfoliated graphene sheets is......
,In vivo retention of poloxamer-based in situ hydrogels for vaginal application in mouse and rat mod
The purpose of this study is to evaluate the in vivo retention capabilities of poloxamer-based in situ hydrogels for vag......
Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: in vitro and in vivo studies
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的:研制氨来呫诺鼻用温敏凝胶喷雾剂,建立其质量控制方法。方法:采用冷法工艺制备氨来呫诺鼻用温敏凝胶喷雾剂,以泊洛沙姆407和......
目的制备丙烯酸和泊洛沙姆407构成的共聚物，研究其温度敏感的原位胶凝性质。方法将泊洛沙姆407溶于丙烯酸单体，引发聚合反应，产物用红......
目的：研究去除泊洛沙姆对温敏凝胶中多糖含量测定干扰的方法,并建立制剂中多糖含量测定方法。方法：采用凝胶冷冻干燥,乙酸乙酯萃取的......
通过对鸡法氏囊高免蛋卵黄进行泊洛沙姆脱脂研究证明:泊洛沙姆对鸡卵黄具有良好的脱脂作用,并且具有脂类自然沉降速度快、对抗体影......
以自由基溶液聚合方法制备了聚(甲基丙烯酸-CO-泊洛沙姆)共聚物水凝胶,研究凝胶的平衡溶胀性质及模型药物(VB12)在溶胀和收缩状态......
扑热息痛片中加入０．２％的泊洛沙姆可以提高其溶出度。考查了泊洛沙姆对扑热息痛的稳定性以及片剂体外溶出速率的影响。......
目的:制备非甾体抗炎药氯诺昔康的固体分散体以提高难溶性氯诺昔康体外溶出速率.研究载体类型及药物-载体混合比例对固体分散体体......
Poly (methacrylie acid co-poloxamer) hydrogel networks were synthesized by free-radical solution polymerization, and the......
目的制备喷昔洛韦（penciclovir，PCV）温度敏感原位凝胶，对其进行了处方优化筛选，并建立其质量控制方法。方法考察含有不同泊洛沙姆407（Plu......
目的研制乳酸环丙沙星眼用即型凝胶。方法以泊洛沙姆407为温敏型材料制备乳酸环丙沙星眼用即型凝胶,通过对胶凝温度的考察确定处方......
采用水溶性非离子型表面活性剂聚醚作基质制备吡哌酸耳用滴丸。与 PEG 制备的滴丸比较,两种滴丸的溶出度和透皮吸收率有显著差异。......
采用熔融法制备尼莫地平（１）与泊洛沙母（２）固体分散体。并测定其体外溶出度。结果均高于１原药。......
从片剂、固体脂质纳米粒系统、栓剂、控释水凝胶、长循环微粒制剂、眼部给药系统等7个方面,介绍了近年来泊洛沙姆在药剂学领域中的......
【目的】研究烟酸对poloxamer 407（P407）诱导的昆明小鼠高血脂动物模型血脂的影响。【方法】昆明小鼠给予烟酸（0.5或1 g/kg）灌胃,连续3......
【目的】高血脂是公认的心血管疾病的危险因素,本实验拟建立一种昆明小鼠通过注射poloxamer 407而形成高血脂的动物模型。【方法】......
目的:观察去甲斑蝥素- 泊洛沙姆407(NCTD-P407)缓释剂瘤内注射治疗中晚期肝癌的疗效.方法:将56例癌灶最大直径为6～12 cm的中晚期肝......
新剂型和新制剂的发展离不开新型药用辅料的开发.一种新型辅料的问世可以借助它开发出一大批新的制剂产品,同时也促进一批制剂产品......
目的:研究布洛芬水溶性凝胶的最佳制备工艺.方法:以正交试验方法筛选基质最佳处方.结果:最佳基质处方为泊洛沙姆p407/p188(15%:20%......
目的：制备美洛昔康温敏性水凝胶并建立其质量控制方法。方法：以泊洛沙姆P407、P188为基质制备温敏性水凝胶；采用紫外分光光度法测定其......
目的：考察泊洛沙姆固体分散体对难溶性药物穿心莲内酯体外溶出特性的影响。方法：以泊洛沙姆为载体材料,采用熔融法制备不同比例的穿......
目的：制备纳米银（Ag-NPs）温敏原位凝胶并考察其流变学性质。方法：采用NaBH4还原AgNO3法制备Ag-NPs,通过四唑鎓盐（XTT）试验考察其对几种常......
目的：制备5-氟尿嘧啶（5-FU）直肠温敏胶膜剂。方法：以泊洛沙姆407（P407）和泊洛沙姆188（P188）为温敏材料制备5-FU直肠温敏胶膜剂,以溶液-凝胶......
Effect of the hyaluronic acid‐poloxamer hydrogel on skin‐wound healing: in vitro and in vivo studies
Background: Recent research into skin injury and wound healing has focused mainly on post‐trauma hemostasis, infection ......
在植物中广泛存在着具有表面活性剂功能的物质,如皂苷、糖脂、磷脂等,这类物质的存在可增加水溶性较低的化合物的溶解度。在进行化......
Evaluation of antihyperlipidemic effect of Polygonum minus,a South East Asian salad plant in poloxam
OBJECTIVE To investigate the antihyperlipidemic effect of methanol and aqueous extracts of the leaves of Polygonum minus......
In this paper, mucoadhesive in-situ gel with poloxamer and hydroxypropylmethylcellulose formulations of itraconazole wer......
目的确定盐酸文拉法辛温敏型原位凝胶的基质处方。方法以不同质量浓度泊洛沙姆作为温敏材料,用卡波姆、聚乙烯吡咯烷酮、羟丙基甲......
目的建立5F-泊洛沙姆固体分散体中5F的含量测定方法.方法采用紫外分光光度法,检测波长为242 nm.结果5F-泊洛沙姆固体分散体中5F在1......
Formulation Development of a Carrageenan Based Delivery System for Buccal Drug Delivery Using Ibupro
Solvent cast films are used as oral strips with potential to adhere to the mucosal surface, hydrate and deliver drugs ac......
Influence of poloxamer 407 on fractional and subfractional composition of serum lipoproteins of mice
Using a novel small-angle X-ray scattering (SAXS) method for determination of fractional and subfractional composition o......
目的建立一种新型Poloxamer 407（P407）温敏性即型凝胶培养体系,以探讨P407凝胶对铜绿假单胞菌药物敏感性的影响。方法临床分离17株铜......
