preclinical相关论文
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通过综述CDE及ICH对生物制品非临床安全性评价的指导原则的内容,比较了不同机构对生物制品非临床安全性评价要求,包括ICHS6（R1）指导......
Three-dimensional aspects of formulation excipients in drug discovery:a critical assessment on orpha
Formulation/pharmaceutical excipients play a major role in formulating drug candidates, with the ob-jectives of ease of ......
目的:建立一种猴体神经毒力实验的组织病理学评价方法,用于疫苗猴体神经毒力非临床安全性评价.方法:通常采用猴丘脑内和脊髓腰椎段......
目的 研究新化合物2-[(4-苄氧基)苯胺基]-6-环己胺基嘌呤(S701)的体外抗肿瘤活性.方法 采用四甲基偶氮唑盐比色法(MTT法),检测S701......
Stem cell therapy or cell therapy has been demonstrated to be a potent treatment intervention in animal models of acute ......
[目的]从天然化合物中初步筛选出具有阻断细胞膜上阴离子(卤素)通道的候选化合物,为新药研发提供实验依据.[方法]利用前期实验已构......
Three-dimensional aspects of formulation excipients in drug discovery:a critical assessment on orpha
Formulation/pharmaceutical excipients play a major role in formulating drug candidates,with the objectives of ease of ad......
Advantages and limitations in the establishment and utilization of patient-derived xenografts in gas
Owing to the high genetic heterogeneity of tumors,small number of therapeutic strategies available,andfrequent presentat......
Background This preclinical study in sheep sought to demonstrate the initial safety and feasibility of a novel transcath......
Bioartificial liver support systems for acute liver failure: A systematic review and meta-analysis o
BACKGROUND Acute liver failure(ALF) has a high mortality varying from 80% to 85% with rapid progress in multi-organ syst......
目的对不同浓度的卡波姆-934和泊洛沙姆-407为基质的甲氧沙林脂质体(LMOP)凝胶体外释药模式进行考察研究,以筛选出较优的凝胶基质......
分子影像学具有无创、高特异性、高敏感度、高分辨率、快速实时成像等优点，用于药物研发有利于缩短研发周期、降低研发成本、提高经......
目的：介绍临床前药物毒理学安全性评价一般毒理学、遗传毒理学、生殖毒性实验、安全药理学和致癌性实验中的数据分析的统计学方法。......
目的构建以分泌型荧光素酶为报告基因的单轮感染流感病毒用于药物作用机制的快速鉴别。方法通过使用分泌型荧光素酶（Gluc）序列替代流......
Orthotopic induction of CH157MN convexity and skull base meningiomas into nude mice using stereotact
Meningioma in vivo research is hampered by the difficulty of establishing an easy and reproducible orthotopic model able......
目的筛选并初步研究微生物来源的卡斯帕酶-3（Caspases-3）抑制剂活性化合物。方法使用E.coli异源表达的卡斯帕酶-3作为靶酶,建立基于C......
Comparison of gene expression in cynomolgus monkeys with preclinical type II diabetes induced by dif
Background:C ynomolgus disease models that are similar to the preclinical stage of human type 2 diabetes mellitus(T2 DM)......
Chagas cardiomyopathy still remains a challenging problem that is responsible for high morbidity and mortality in Centra......
Over the past two decades, regenerative therapies usingstem cell technologies have been developed for variousneurologica......
Intracerebral hemorrhage （ICH） is a very complexpathology, with many different not fully elucidatedetiologies and prognost......
Hepatic encephalopathy(HE)is a major complication that is closely related to the progression of end-stage liver disease.......
Mesenchymal stem cells (MSCs) are multipotent progenitor cells with therapeutic potential against autoimmune diseases, i......
目的探讨采用已建立的细胞模型初筛抗人免疫缺陷病毒（HIV）药物的可靠性。方法以齐多夫定为阳性对照,使用HIV-1急性感染系统（MT-4/HIV-......
在壮医药理论的指导下，重点对有明显资源优势和抗乙肝药效优势的火炭母进行药材品种整理及抗乙肝病毒活性物质的筛选与纯化，制成胶囊......
Developers of drugs, biologicals, and medical devices must ensure product safety, demonstrate medical benefit in people,......
Dynamic Contrast-Enhanced MRI of Mouse Liver: A Feasibility Study Using a Dual-Input Two-Compartment
Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been widely applied to evaluate microcirculatory para......
Characteristics of a primate model of focal motor cortical seizures suitable for preclinical testing
Background and objective: Generating and characterizing primate models of epileptic seizures are important for understan......
Oral treatment with plecanatide or dolcanatide attenuates visceral hypersensitivity via activation o
AIM To investigate the effects of plecanatide and dolcanatide on maintenance of paracellular permeability,integrity of t......
AIM: To expand hematopoietic/progenitor stem cells (HS/PCs) from umbilical cord blood (UCB) and prepare the HS/PC produc......
WJC 6~th Anniversary Special Issues(3):Cardiomyopathy Hypertrophic cardiomyopathy in 2013:Current sp
Hypertrophic cardiomyopathy(HCM),the most variable cardiac disease in terms of phenotypic presentation and clinical outc......
