Composite scaffold with gradient content of simvastatin for enhanced large cranial defect repair

来源 :Fourth Symposium on Innovative Polymers for Controlled Deliv | 被引量 : 0次 | 上传用户:huangyuli
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
  Bioactive scaffolds-based tissue engineering is a promising strategy for repairing cranial defects[1].How to impart the scaffolds with appropriate physiochemical properties and osteoinductivity remains challenging.For cranial defect repair,it is more difficult to repair the central part.
其他文献
Fluorescent conjugated polymer nanoparticles have wide applications in display device,bioimaging and sensing due to their superior fluorescence properties.Latent fingerprints (LFP) have been particula
Efficient delivery of proteins and peptides into cells remains a major challenge due to the presence of multiple barriers in intracellular protein delivery.In recent years,functional nanoparticles hav
Nanoscale stimuli-responsive systems for gene and drug delivery have recently received tremendous attention[1].The systems that sensitive to a specific trigger may provide a specific release of the pa
Over the past decades,much effort has been devoted to design of novel sustained/controlled drug delivery systems.However,as commonly used fluorescent components,organic dyes usually suffer from rapid
Adjuvant chemotherapy is the most important strategy to prevent the recurrence of bladder cancer after surgery[1].However,the low permeability effect and short residence time of intravesical drug make
Nanocarriers have shown great potential for targeting delivery of therapeutic molecules to tumors[1].Compared to small molecule anti-cancer drugs,nanomedicines with the features of tumor targeting,lon
Synthetic oligodeoxynucleotides (ODNs) containing unmethylated CpG motifs activate innate and adaptive immune responses by activation of Toll-like receptor 9 (TLR 9)[1,2].CpG ODNs show strong potentia
Matrine (MAT) is widely used in the treatment of ulcerative colitis[1].However,it cannot reach an effective concentration in the colorectal area,leading to low availability and severe toxic side-effec
Smart nanogels consisting of cross-linked network can be responsive to bio-stimuli,such as pH and redox.Dextrin has been widely used for drug delivery systems because of its biodegradability and noncy
Stimulus-responsive gene vectors,that release gene in response to endosomal pH or cytoplasmic glutathione (GSH) have attracted increasing interests in tumor therapy[1,2].Developing gene-delivery syste