The middle cerebral artery(MCA)is one of the most common sites of symptomatic intracranial atherosclerosis.We assessed the safety and efficacy of Wingspan stents for the treatment of symptomatic atherosclerotic MCA stenosis.Sixty-one cases of symptomatic MCA stenosis with narrowing of at least 70％ among 61 patients were treated using Wingspan stents from March 2007 to December 2010.Clinical outcomes and imaging features were recorded and analyzed.The technical success rate was 98.4％.The rate of procedure-related complications during the periprocedural period(30 days)was 4.9％(3/61),which included one ischemic complication and two hemorrhagic complications with no permanent neurological sequelae.The mean degree of stenosis decreased from 76.8±6.0％ to 12.0±11.5％ following treatment.Forty-five patients(74％)were available for follow-up imaging with digital subtraction arteriography.ISR was documented in 7 of these patients.A total of 61 patients were available for a clinical follow-up.Four ischemic events(6.6％)occurred during the follow-up period,which were all transient ischemic attacks including two symptomatic ISR.The cumulative probability of adverse event was 11.5％ at 1 year.83.6％(51/61)patients had their follow-up visit more than 12 months after procedure,and no adverse event was found beyond 12 months after procedure.Percutaneous transluminal angioplasty and the stenting of the MCA was safe and associated with low periprocedural complication rate.It may bring a good long-term benefit.Prospective randomized controlled trials and further longterm follow-up are needed to provide more adequate statistical evidence to support our findings.