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<正>Natural Product is a very important resource for anticancer lead finding.One of the most promising research areas of Shanghai Institute of Materia Medica (SIMM) is novel anticancer agent discovery from Traditional Chinese Medicine.Camptothecin is a natural alkaloid isolated from Camptotheca acuminata.SIMM developed its derivative 10-hydroxycamptothecin in 1970s and it is still widely used in China.Recently, we synthesized a novel amphoteric 9-substituted camptothecin, Chimmitecan, which confers unproved anti-cancer pharmacological profiles both in vitro and in vivo.Saivicine, a natural product derivative from Salvia prionitis, is a new topoisomerase II inhibitor.It also showed prominent anti-multidrug resistance effects and transcription factor c-Jun played a principal role in exerting this effect.Pseudolarix acid B got from Chinese plant Pseudolarix kaempferi.It caused depolymerization of tubulin by binding to a novel site, and abrogated secretion of VEGF due to reducing hypoxia-inducible factor la protein by promoting proteasome pathway, which may responsible for its powerful anti-angiogenic effect