2. 您的位置
3. 首页
4. 会议论文
5. Discovery of a potent and orally-available D-amino acid oxidase inhibitor for the management of chro

Discovery of a potent and orally-available D-amino acid oxidase inhibitor for the management of chro

来源 :The 12th Meeting of the Asia Pacific Federation of Pharmacol | 被引量 : 0次 | 上传用户：moxigege

【摘 要】

：

Aim: It has been shown that spinal D-amino acid oxidase (DAAO) might be a potential molecular target for the treatment of chronic pain and morphine tolerance to analgesia.This study evaluated the in v

【作 者】

：

Jun LU Dong-sheng XEI Teng-fei LI Yan-chao WANG Jun-jun CUI Jin XIE Nian GONG Lei FU Yong-xiang WANG 

【机 构】

：

School of Pharmacy, Shanghai Jiao Tong University,Shanghai 200240, China

【出 处】

：

The 12th Meeting of the Asia Pacific Federation of Pharmacol

【发表日期】

：

2013年4期

【关键词】

：

DAAO inhibitor Compound 15 morphine tolerance neuropathic pain formalin-induced 

下载到本地 , 更方便阅读

下载此文 赞助VIP

声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架

论文部分内容阅读

Aim: It has been shown that spinal D-amino acid oxidase (DAAO) might be a potential molecular target for the treatment of chronic pain and morphine tolerance to analgesia.This study evaluated the in vitro and in vivo effects of Compound 15, a newly discovered DAAO inhibitor.

其他文献

Effect of magnesium salts on oxidative protein modification in rats fed low magnesium diet

Aim: The study was to compare level of protein carbonyls (PC) as biomarker of oxidative stress in hypomagnesiemic rats before and after treatment with different magnesium (Mg) salts.Methods: Experimen

会议

magnesium deficiencycarbonyl products of protein oxidationmagnesium chloridem

Comparison of 24-h ocular hypotensive effect of single drop application of enalaprilat and losartan

Aim: Angiotensin converting enzyme inhibitors and angiotensin Ⅱ receptor blockers are currently attractive as potential drugs to reduce elevated intraocular pressure (IOP).The purpose of the present s

会议

enalaprilatlosartanintraocular pressuresteroid-induced ocular hypertension

3-Hydroxyphthallc anhydride-modified human serum albumin as a microbicide candidate for preventing s

Aim: Female-controlled topical microbicides for prevention of sexually transmitted diseases (STDs) are a diverse group of active ingredients that are capable of affecting microorganisms growth in vari

会议

3-hydroxyphthalic anhydride human serum albuminmicrobicideHIV-1 sexual transmi

Calcium/calmodulin kinase Ⅱ and protein kinase C in dorsal raphe nucleus involved in sleep regulatio

Aim: The dorsal raphe nucleus (DRN) is critically involved in sleep-wake regulation, but our understanding of the mechanisms of this regulation remains incomplete.The present study was designed to det

会议

calcium/calmodulin kinase Ⅱprotein kinase CDRNsleep

The auxiliary GABA(B) receptor subunits KCTD12 and KCTD16 differentially modulate receptor function

Aim: KCTD12 and KCTD16 were recently identified as GABAB receptor auxiliary subunits, yet their functional significance has yet to be clearly elucidated.Here we characterised the impact of human KCTD1

会议

GABAB receptorKCTD

RhoA/ROCK pathway regulates canonical transient receptor potential channels in hypoxic pulmonary vas

Aim: Hypoxic pulmonary vasoconstriction (HPV) can be modulated through either elevation of [Ca2+]i by Ca2+-dependent mechanism or inhibition of MLCP by Ca2+-independent mechanism.TRPC channels constit

会议

HPVRhoARho-kinaseTRPC channels

H2S protects endothelium cell against Hcy-induced apoptosis and promotes cystathionine-γ-lyase expre

Aim: To investigate the role of the H2S effect in atherosclerosis (AS).Methods: The HUVECs were divided into the following groups: (1) the control group; (2) the DLHomocysteine(Hcy) 10, 20, 40, and 20

会议

atherosclerosishomocysteinecystathionine-γ-lyasehydrogen sulfide (H2S)human

Inhibitory effect and mechanism of calcitonin gene-related peptide on bleomycin-induced lung fibrosi

Aim: Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter in sensory nerves.It has been reported that the expression of CGRP in lung was decreased in PF patients evoked by crystall

会议

calcitonin gene-related peptideERK1/2eukaryotic initiation factor 3apulmonary

Bis-(2-ethylhexyl) phthalate suppresses myogenic differentiation and promotes adipogenic differentia

Aim: Bis-(2-ethylhexyl) phthalate (DEHP) is a manufactured chemical that makes plastic more flexible.Exposure to DEHP has recently been shown to possess a potential health hazard in premature infants

会议

bis-(2-ethylhexyt) phthalatemyogenesisadipogenesisskeletal muscle progenitor

The effects of high-purine diet on the blood pressure and kidney function of mice

Aim: Referring to the relation between hypertension and long-term high-purine diet, we established the hypertension model mice by feeding with high-purine food, which is similar to human diseases.Meth

会议

hypertensionmodelmicerenal functionhigh purine