【摘 要】
：
FTY720 is a fungus derived metabolite which has been shown to have potent anticancer properties in a number of tumours without causing severe toxicity.Previ
【机 构】
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Department of Anatomy and Cancer Research Centre Li Ka Shing Faculty of Medicine The University of H
【出 处】
：
BIT‘s2nd Annual World Cancer Congess-2009 (2009第二届癌症大会)
论文部分内容阅读
FTY720 is a fungus derived metabolite which has been shown to have potent anticancer properties in a number of tumours without causing severe toxicity.Previously, we reported that FTY720, suppressed the in vivo growth of CWR22R, an androgen independent (AI) prostate cancer xenograft through inhibition of proliferation, angiogenesis and apoptosis.In the present study, we investigated whether this compound could induce reversal of epithelial-to-mesenchymal transition (EMT), a crucial event during prostate carcinogenesis, thus suppressing the aggressiveness of AI prostate cancer.Using both western blot analysis and immunofluorescem staining, we found that FTY720 treatment led to a decrease in mesenchymal markers expression, concomitantly with an increase in epithelial markers expression in a dose-and time-dependent manner.
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