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5. Targeted disruption of □-arrestin 2-mediated signaling pathwaysby aptamer chimeras leads to inhibiti

Targeted disruption of □-arrestin 2-mediated signaling pathwaysby aptamer chimeras leads to inhibiti

来源 :中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议 | 被引量 : 0次 | 上传用户：wh820228

【摘 要】

：

β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerouscritical cellular pathways, are attractive therapeutic targets because they promotetumorigenesis in sev

【作 者】

：

孙金鹏 Jonathan Kotula Jeff Kovac 

【机 构】

：

山东大学 Duke Duke University

【出 处】

：

中国生物化学与分子生物学会第十一次会员代表大会暨2014年全国学术会议

【发表日期】

：

2014年3期

【关键词】

：

arrestin leukemia 

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β-arrestins, ubiquitous cellular scaffolding proteins that act as signaling mediators of numerouscritical cellular pathways, are attractive therapeutic targets because they promotetumorigenesis in several tumor models.However, targeting scaffolding proteins with traditionalsmall molecule drugs has been challenging.

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