【摘 要】
：
Dendrimers are highly branched,symmetrical macromolecules of nano-sized dimensions,consisting of a central core,repeating units and terminal functional groups.When used as drug nanocarriers,the dense
【机 构】
：
Tsinghua University Shenzhen Graduate School,Shenzhen 518055,China
【出 处】
：
The Third Symposium on Innovative Polymers for Controlled De
论文部分内容阅读
Dendrimers are highly branched,symmetrical macromolecules of nano-sized dimensions,consisting of a central core,repeating units and terminal functional groups.When used as drug nanocarriers,the dense and compact dendritic structure of dendrimers avoids chain entanglement and reduces hydrodynamic radius in comparison with the linear copolymers with identical molecular masses.Moreover,they could have higher drug loading content (LC) and drug encapsulation efficiency (EE).Boltorn H40,a dendrimer-like aliphatic polyester with a large number of terminal hydroxyl groups,may be a satisfactory macro-initiator (inner core) of ring-opening polymerization,which can thus be employed to formulate hydrophobic anti-cancer drugs of high drug loading and high drug encapsulation efficiency due to its globular architecture [1].
其他文献
Polyethylenimine (PEI) is one of the most successful cationic polymers for gene delivery.PEI of high molecular weight provides high transfection efficiency but at the same time a high cytotoxicity,whi
Carbon nanotubes (CNTs) have attracted tremendous attention as potential multifunctional drug delivery systems,owing to their enhanced cellular uptake,and high surface area that allows attachment of m
Electrospinning is a simple and robust method to produce micro and nanometer diameter fibers to mimic the architecture of extracellular matrix (ECM) for tissue engineering.However,the relatively small
The deoxycholic acid (DA),which is a class of bile adds,is composed of hydrophilic groups and hydrophobic groups.In order to increase the transfection efficiency and to decrease the cytotoxicity,DA wa
Hydroxyapatite/poly(L-lactide) (HA/PLLA) composites have been widely used as bone tissue engineering scaffolds or bone implant [1].However,the phase compatibility between HA and polymer matrix has lim
Successful controlled release for intracellular delivery requires both sufficient cellular uptake and suitable internalization pathways.With superior cellular uptake capacity and potentially direct tr
Articular cartilage defects can be caused by disease,trauma,or sports-related injury.Without blood vessels,lymphatic and nerve tissue,the damaged articular cartilage shows limited capacity of self-rep
Stimuli-responsive hollow micro-and nano-capsules,especially for capsules which can respond to multiple-stimuli in a predictable manner,are finding increasing applications in biomedicine and drug deli
The synthesis and modification of poly(glycidyl methacrylate) (PGMA) have arose interests of many researchers,and diverse assemblies,including micelles,reverse micelles,capsules,and nanoparticles have
Alveolar osteitis (AO) is the most common complication following extraction or surgical removal of tooth[1].The purpose of this study was to create apolymeric double-material formulation as an effecti