【摘 要】
：
Breast cancer is the commonest cause of cancer in women.Estrogen is implicated in its development, and often it.progresses to hormone refractory disease in
【机 构】
：
Department of Pathology The University of Hong Kong China
【出 处】
：
(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
论文部分内容阅读
Breast cancer is the commonest cause of cancer in women.Estrogen is implicated in its development, and often it.progresses to hormone refractory disease in which the cancer no longer depends on hormonal stimulation for survival and proliferation.Although most estrogen receptor (ERα) positive breast cancers initially respond to tamoxifen therapy,tamoxifen-resistant tumors eventually develop which are a cause for treatment failure andmortality.FOXO3a transcription factor, a downstream target of the PI3K/Akt signaling pathway, is an important intracellular mediator of ERα expression in breast cancer cells.It was recently shown that persistent induction of FOXO3a activity in chronic myeloid leukemia (CML) cell-lines by doxorubicin treatment can enhance survival through a feedback mechanism that involves enhanced PI3K/Akt activity.
其他文献
The goal of this study is to elucidate the genes and signaling pathways regulating oncogenic properties of cancer cells especially the survival and invasive
近年来,随着教学质量的不断提高,各个教学领域出现了新的教学模式.高职院校的教学宗旨是培养实用性的人才,就旅游管理而言,很多高职院校在引对高职旅游管理专业现代学徒制这
怎样养好兜兰兜兰原产印度，是多年生草本花卉。目前，它是我国冬季温室花卉中的佼佼者。兜兰的花大，很美丽，多数单生，外有花苞，左右花瓣相称，中间唇形花瓣长得好像口袋，又像倒挂的拖鞋
在贵刊今年第5期彩页上赏读了黄明山先生的《轻歌曼舞》后,一种清新之感油然而生。先看那强壮的主干左上、右斜,沿中轴线微曲向上,自然结顶;左右两侧的分枝比例协调,位置合
Pathological lesions often result in a change in tissue consistency that allows for detection by clinical palpation.However, palpation is subjective and lim
教育是社会发展的基础推动力,受到社会各界的广泛重视.随着教育改革不断深化,素质教育对初中体育课也提出了更高的要求.激发学生参与体育教学的积极性,传承奥林匹克体育精神,
The peroxisome proliferator-activator receptors are ligand-activated nuclear receptors that include PPARα, PPARγ and PPAR & PPARγ, originally cloned as a
近年来,农村初中生的辍学现象引起了社会广泛关注,越来越多人们对导致学生辍学的原因进行了深入研究,并努力寻找对策来将辍学率降低.本文分析了农村初中生辍学的原因及对教学
我国的ppp模式作为公共服务供给机制的重大创新越来越受到大众的关注,使社会资本有效促进我国经济高质量快速,在改善民生方面也起到了重大作用.本文对于中国的ppp模式的概念
杨靖宇离家时儿子仅两岁,女儿才三个月1905年2月26日出生于河南省驻马店地区确山县李湾村的杨靖宇,原名马尚德,字骥生,乳名马顺清。1932年春,出任中共哈尔滨市委书记不久的