【摘 要】
：
The peroxisome proliferator-activator receptors are ligand-activated nuclear receptors that include PPARα, PPARγ and PPAR & PPARγ, originally cloned as a
【机 构】
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Department of Cancer Biology Kimmel Cancer Center Thomas Jefferson University USA
【出 处】
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(BITs 3rd Annual World Cancer Congress-2010, Breast Cancer C
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The peroxisome proliferator-activator receptors are ligand-activated nuclear receptors that include PPARα, PPARγ and PPAR & PPARγ, originally cloned as a transcription factor involved in fat cell differentiation, is activated by endogenous ligands, such as fatty acids produced by sterol response element binding protein 1 (SREBP1) and fatty acids synthase (FASN) pathway and synthetic ligands including the thiazolidinediones (TZD).The role of PPARγ in tumorigenesis remains poorly understood in regards to growth inhibition effects in cultured cells and in NMU or NMBA-indueed mammary tumorigenesis.PPARγ is expressed in a variety of cancer cells.The addition of ligand activates the receptor by inducing a conformational change in the receptor, which can be recapitulated by mutation.
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