Chronic stressful events are key risk factors for major depressive disorder (MDD),yet some individuals exposed to stressful eventsdo not develop MDD.This disparity suggests the significance of resilience to deleterious stress effects.However,the underlyingmolecular mechanisms of stress resilience are poorly understood.In the present study,the chronic mild stress (CMS) rat model ofdepression was used to reveal the individual differences in stress response.