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Objective:Nesfatin-1,an anorexigenic peptide involved in energy homeostasis.Recently,peripheral nesfatin-1 was reported to participate in the development of T2DM and stimulated free fatty acid.The main objective of this study was to characterize the mechanisms by which central nesfatin-1 regulates lipid metabolism in Streptozotocin-induced T2DM and whether through sympathetic nervous system.