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As the main active alkaloids of mulberry, 1-deoxynojirimycin (1-DNJ, pKa=7.53), and its analogues fagomine (pKa=8.4), 1, 4-dideoxy-1, 4-imino-D-arabinitol (DAB, pKa=8.88) have been received special attention as the most promising α-glucosidase inhibitors.