【摘 要】
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Aim: The treatment failure of methicillin resistant Staphylococcus aureus (MRSA) infections and emergence of vancomycin-resistant Staphylococcus aureus (S aureus) urgently requires developing new anti
【机 构】
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Department of Pharmacology,School of Pharmacy,the Fourth Military Medical University,Xi-an,China
【出 处】
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The 12th Meeting of the Asia Pacific Federation of Pharmacol
论文部分内容阅读
Aim: The treatment failure of methicillin resistant Staphylococcus aureus (MRSA) infections and emergence of vancomycin-resistant Staphylococcus aureus (S aureus) urgently requires developing new antimicrobials.Methods: Three new biscoumarin derivatives, 3,3-(4-nitrobenzylidene)-bis-(4-hydroxycoumarin) (NBH), 3,3-(4-methoxybenzylidene)-bis-(4-hydroxycoumarin) (MBH), and 3,3-(4-chloromethylbenzylidene)-bis-(4-hydroxycoumarin) (CBH), were synthesized and characterized by FT-IR, 1H NMR, HRMS and single crystal X-raycrystallography.
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