【摘 要】
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α-Substituted nitrogen-containing heterocycles(N-heterocycles),like tetrahydroisoquinolines(THIQs),tetrahydroquinolines,and pyridine,represent ubiquitous structural motifs in numerous alkaloids exhibi
【机 构】
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Department of Natural Products Chemistry,Key Lab of Chemical Biology(MOE),School of Pharmaceutical S
【出 处】
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全国药物化学学术会议暨第四届中英药物化学学术会议
论文部分内容阅读
α-Substituted nitrogen-containing heterocycles(N-heterocycles),like tetrahydroisoquinolines(THIQs),tetrahydroquinolines,and pyridine,represent ubiquitous structural motifs in numerous alkaloids exhibiting a wide range of pharmacological activities.Among them,1-benzyl,-aryl and-arylethyl THIQs are the most widely distributed and serve as key intermediates in the synthesis and biosynthesis of other types of alkaloids.Inspired by the importance of these compounds in modern pharmacology,significant effort has been devoted to their construction,especially in stereoselective manner,and current syntheses mainly rely on the functional group transformations like the sequential Bischler-Napieralski cyclization/reduction and Pictet-Spengler condensation.
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