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  5. Preparation and in vitro evaluation of a MRI contrast agent based on aptamer-targeted liposomes

Preparation and in vitro evaluation of a MRI contrast agent based on aptamer-targeted liposomes

来源 :2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会 | 被引量 : 0次 | 上传用户：liuchun9876
【摘 要】
：
Objective: To enhance the effective diagnosis of tumor by magnetic resonance imaging (MRI), aptamer-targeted liposomes combined with gadolinium (Gd) were designed and constructed as a novel MRI contra
【作 者】
：
Lan-Xin Zhang Kun-Feng Li Meng-Jie Gu Huan Wang Li-Si Liu Zhuo-Zhao Zheng Zhen-Jun Yang Tian-Yuan Fan 
【机 构】
：
State Key Laboratory of Natural and Biomimetic Drugs,School of Pharmaceutical Sciences,Peking Univer
【出 处】
：
2014年中国药物制剂大会——中国药学会药剂专业委员会年会、第六届亚洲阿登制药技术研讨会暨国际控释协会中国分会年会
【发表日期】
：
2014年8期
【关键词】
：
Aptamer-targeted Liposomes MRI Gadolinium 
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　　Objective: To enhance the effective diagnosis of tumor by magnetic resonance imaging (MRI), aptamer-targeted liposomes combined with gadolinium (Gd) were designed and constructed as a novel MRI contrast agent.The aptamer used in this study was a modified GBI-10, which has high affinity to tenascin C (TN-C) overexpressed in various tumor.Method: Non-targeted liposomes (NLs) were first prepared by lipid film hydration and extrusion method.
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