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Largemouth Bass Micropterus salmoides is an economically important freshwater fish cultured in China.The new emerging viral diseases evoked by iridovirus and rhabdovirus have caused great economic losses in aquaculture.To better exploring the pathogenesis of Largemouth Bass virus (LMBV), a ranavirus isolate, we investigated the underlying mechanism involved in viral replication and virus induced cell death in vitro.