Objective This study explore the reversion of 2,6-Diisopropylphenol and NMDA receptor antagonist against the impairment of learning-memory and the hyperphosphorylation of protein Tau induced by electroconvulsive shock in depressed rats.Methods As the analysis of variance of factorial design set up two intervention factors which are the electroconvulsive shock groups (two levels: no disposition;A course of electroconvulsive shock) and the drug intervention groups (three level: ip Saline;ip NMDA receptor antagonist MK-801;ip 2,6-Diisopropylphenol).